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Jackie Goldstein

Researcher at Harvard University

Publications -  14
Citations -  13365

Jackie Goldstein is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 9, co-authored 10 publications receiving 11059 citations. Previous affiliations of Jackie Goldstein include Broad Institute.

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Analysis of protein-coding genetic variation in 60,706 humans

Monkol Lek, +106 more
- 18 Aug 2016 - 
TL;DR: The aggregation and analysis of high-quality exome (protein-coding region) DNA sequence data for 60,706 individuals of diverse ancestries generated as part of the Exome Aggregation Consortium (ExAC) provides direct evidence for the presence of widespread mutational recurrence.
Posted ContentDOI

Analysis of protein-coding genetic variation in 60,706 humans

Monkol Lek, +72 more
- 30 Oct 2015 - 
TL;DR: The aggregation and analysis of high-quality exome (protein-coding region) sequence data for 60,706 individuals of diverse ethnicities generated as part of the Exome Aggregation Consortium (ExAC) provides direct evidence for the presence of widespread mutational recurrence.
Journal ArticleDOI

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Christian R. Marshall, +329 more
- 01 Jan 2017 - 
TL;DR: In this article, a centralized analysis pipeline was applied to a SCZ cohort of 21,094 cases and 20,227 controls, and a global enrichment of copy number variants (CNVs) was observed in cases (odds ratio (OR) = 1.11, P = 5.7 × 10-15), which persisted after excluding loci implicated in previous studies.
Posted ContentDOI

A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects

Christian R. Marshall, +255 more
- 23 Feb 2016 - 
TL;DR: A collaborative effort in which a centralized analysis pipeline is applied to a SCZ cohort, finding support at a suggestive level for nine additional candidate susceptibility and protective loci, which consist predominantly of CNVs mediated by non-allelic homologous recombination (NAHR).
Journal ArticleDOI

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Vassily Trubetskoy, +432 more
- 08 Apr 2022 - 
TL;DR: In this article , a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals was conducted, and the authors reported common variant associations at 287 distinct genomic loci.