J
Jacob Bak Holm
Researcher at University of Copenhagen
Publications - 26
Citations - 2870
Jacob Bak Holm is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 18, co-authored 20 publications receiving 1968 citations.
Papers
More filters
Journal ArticleDOI
Human gut microbes impact host serum metabolome and insulin sensitivity
Helle Krogh Pedersen,Valborg Gudmundsdottir,Henrik Nielsen,Tuulia Hyötyläinen,Tuulia Hyötyläinen,Trine G. Nielsen,Benjamin A. H. Jensen,Kristoffer Forslund,Falk Hildebrand,Falk Hildebrand,Edi Prifti,Edi Prifti,Gwen Falony,Florence Levenez,Joël Doré,Ismo Mattila,Ismo Mattila,Damian R. Plichta,Päivi Pöhö,Päivi Pöhö,Lars Hellgren,Manimozhiyan Arumugam,Shinichi Sunagawa,Sara Vieira-Silva,Torben Jørgensen,Torben Jørgensen,Jacob Bak Holm,Kajetan Trošt,Karsten Kristiansen,Susanne Brix,Jeroen Raes,Jeroen Raes,Jun Wang,Torben Hansen,Torben Hansen,Peer Bork,Søren Brunak,Søren Brunak,Matej Orešič,Matej Orešič,Matej Orešič,S. Dusko Ehrlich,S. Dusko Ehrlich,Oluf Pedersen +43 more
TL;DR: It is shown how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals and suggested that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.
Journal ArticleDOI
Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism
Alexander Duscha,Barbara Gisevius,Sarah Hirschberg,Nissan Yissachar,Gabriele I. Stangl,Eva Eilers,Eva Eilers,Verian Bader,Stefanie Haase,Johannes Kaisler,Christina David,Ruth Schneider,Riccardo Troisi,Daniel Zent,Tobias Hegelmaier,Nikolaos Dokalis,Sara Gerstein,Sara Del Mare-Roumani,Sivan Amidror,Ori Staszewski,Gereon Poschmann,Kai Stühler,Frank Hirche,András Balogh,Stefan Kempa,Pascal Träger,Mario M. Zaiss,Jacob Bak Holm,Megan G. Massa,Henrik Nielsen,Andreas Faissner,Carsten Lukas,Sören Gatermann,Markus Scholz,Horst Przuntek,Marco Prinz,Sofia K. Forslund,Konstanze F. Winklhofer,Dominik N. Müller,Ralf A. Linker,Ralf Gold,Aiden Haghikia +41 more
TL;DR: It is suggested that PA can serve as a potent immunomodulatory supplement to MS drugs and as an add-on to MS immunotherapy.
Journal ArticleDOI
Physiological role of taurine--from organism to organelle.
TL;DR: Taurine homeostasis in cells and organelles is described with emphasis on taurine biophysics/membrane dynamics, regulation of transport proteins involved in active and passive t aurine release as well as physiological processes, for example, development, lung function, mitochondrial function, antioxidative defence and apoptosis which seem to be affected by a shift in the expression of the taurin transporters and/or the cellular taurines.
Journal ArticleDOI
Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli.
Jacob Bak Holm,Daniel Sorobetea,Pia Kiilerich,Yuliaxis Ramayo-Caldas,Jordi Estellé,Tao Ma,Lise Madsen,Karsten Kristiansen,Marcus Svensson-Frej +8 more
TL;DR: The results demonstrate that chronic parasite infection strongly influences the intestinal microbiota and the adaptive immune system, and illustrate the complex interactions between these factors in the intestinal tract, and contribute to furthering the understanding of this interplay.
Journal ArticleDOI
Prevotella-to-Bacteroides ratio predicts body weight and fat loss success on 24-week diets varying in macronutrient composition and dietary fiber: results from a post-hoc analysis.
Mads F. Hjorth,Trine Blædel,Line Q. Bendtsen,Janne K. Lorenzen,Jacob Bak Holm,Pia Kiilerich,Henrik Munch Roager,Henrik Munch Roager,Karsten Kristiansen,Lesli H. Larsen,Arne Astrup +10 more
TL;DR: Individuals with high P/B lost more body weight and body fat compared to individuals with low P/ B, confirming that individuals with a highP/B are more susceptible to weight loss on a diet rich in fiber.