J
Jacob O’Brien
Researcher at York University
Publications - 17
Citations - 3073
Jacob O’Brien is an academic researcher from York University. The author has contributed to research in topics: Trophoblast & microRNA. The author has an hindex of 10, co-authored 15 publications receiving 1418 citations. Previous affiliations of Jacob O’Brien include University of Toronto.
Papers
More filters
Journal ArticleDOI
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation.
TL;DR: An update on canonical and non-canonical miRNA biogenesis pathways and various mechanisms underlying miRNA-mediated gene regulations and the current knowledge of the dynamics of miRNA action and of the secretion, transfer, and uptake of extracellular miRNAs is provided.
Journal ArticleDOI
MicroRNAs: crucial regulators of placental development.
TL;DR: An overview of canonical and non-canonical pathways of miRNA biogenesis and mechanisms of mi RNA actions is provided and the current knowledge of the role of miRNAs in placental development is highlighted.
Journal ArticleDOI
miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway
Mohamed Salem,Jacob O’Brien,Stefanie Bernaudo,Heba Shawer,Gang Ye,Jelena Brkić,Asma Amleh,Barbara C. Vanderhyden,Basel Refky,Burton B. Yang,Sergey N. Krylov,Chun Peng +11 more
TL;DR: Low FOXA2/high VCAN levels mediate the tumor-promoting effects of miR-590-3p and negatively correlate with ovarian cancer survival and are demonstrated to promote EOC development via a novel FoxA2-VCAN pathway.
Journal ArticleDOI
MicroRNA-218-5p Promotes Endovascular Trophoblast Differentiation and Spiral Artery Remodeling
Jelena Brkić,Caroline Dunk,Jacob O’Brien,Guodong Fu,Guodong Fu,Lubna Nadeem,Lubna Nadeem,Yan-Ling Wang,David Rosman,Mohamed Salem,Oksana Shynlova,Oksana Shynlova,Issaka Yougbaré,Issaka Yougbaré,Heyu Ni,Stephen J. Lye,Stephen J. Lye,Chun Peng +17 more
TL;DR: This study elucidates the role of an miRNA in enEVT differentiation and spiral artery remodeling and suggests that downregulation of miR-218-5p contributes to PE development.
Journal ArticleDOI
Incidence, clinical features, and outcomes of COVID-19 in Canada: impact of sex and age.
TL;DR: It is found that females had a lower incidence rate than males between the ages of 20s to 70s, and this sex-based difference is more evident in females of the reproductive ages (20–49) than in postmenopausal patients (60s or older).