J
Jacob Selhub
Researcher at Tufts University
Publications - 351
Citations - 46586
Jacob Selhub is an academic researcher from Tufts University. The author has contributed to research in topics: Homocysteine & Hyperhomocysteinemia. The author has an hindex of 106, co-authored 351 publications receiving 44698 citations. Previous affiliations of Jacob Selhub include Harvard University & Tufts Medical Center.
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Journal ArticleDOI
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
Sudha Seshadri,Alexa S. Beiser,Jacob Selhub,Paul F. Jacques,Irwin H. Rosenberg,Ralph B. D'Agostino,Peter W.F. Wilson,Philip A. Wolf +7 more
TL;DR: Dementia developed in 111 subjects, including 83 given a diagnosis of Alzheimer's disease, over a median follow-up period of eight years, and plasma levels of folate and vitamins B12 and B6 increased.
Journal ArticleDOI
Vitamin Status and Intake as Primary Determinants of Homocysteinemia in an Elderly Population
TL;DR: A strong association between homocysteine concentration and folate, vitamin B12, and vitamin B6 status, as well as age is indicated, suggesting that a substantial majority of the cases of high homocy steine in this older population can be attributed to vitamin status.
Journal ArticleDOI
Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis
Robert Clarke,Rory Collins,Sarah Lewington,Ann E. Donald,G. Alfthan,J. Tuomilehto,Egil Arnesen,Kaare H. Bønaa,Jacques Blacher,Godfried H.J. Boers,Andrew G. Bostom,M. L. Bots,D. E. Grobbee,Lars Brattström,Monique M.B. Breteler,A. Hofman,John C. Chambers,Jaspal S. Kooner,B. M. Coull,R. W. Evans,Lewis H. Kuller,S. Evers,Aaron R. Folsom,G. Freyburger,F. Parrot,J. Genest Jr,K. Dalery,I. M. Graham,Leslie Daly,Ellen K. Hoogeveen,Pieter J. Kostense,C.D.A. (Coen) Stehouwer,P. N. Hopkins,Paul F. Jacques,Jacob Selhub,F. C. Luft,P. Jungers,Arne Lindgren,Y. I. Lolin,F. Loehrer,Brian Fowler,Mohammad Azam Mansoor,M. R. Malinow,Pierre Ducimetière,Ottar Nygård,Helga Refsum,S. E. Vollset,Per Magne Ueland,G. S. Omenn,S. A. A. Beresford,J. M. Roseman,H. H. Parving,M. A. Gall,Ivan J. Perry,S Ebrahim,A. G. Shaper,Killian Robinson,D. W. Jacobsen,Steven M. Schwartz,David S. Siscovick,Meir J. Stampfer,C. H. Hennekens,Edith J. M. Feskens,Daan Kromhout,J. Ubbink,P. Elwood,J. Pickering,Petra Verhoef,A. Von Eckardstein,Helmut Schulte,Gerd Assmann,Nicholas J. Wald,M. R. Law,Peter H. Whincup,D. E. L. Wilcken,Paul Sherliker,P. Linksted,G Davey Smith +77 more
TL;DR: This meta-analysis of observational studies suggests that elevated homocysteine is at most a modest independent predictor of IHD and stroke risk in healthy populations.
Journal ArticleDOI
Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations
Paul F. Jacques,A. G. Bostom,R. R. Williams,R. C. Ellison,John H. Eckfeldt,Irwin H. Rosenberg,Jacob Selhub,Rima Rozen +7 more
TL;DR: Individuals with thermolabile MTHFR may have a higher folate requirement for regulation of plasma homocysteine concentrations; folate supplementation may be necessary to prevent fasting hyperhomocysteinemia in such persons.
Journal ArticleDOI
Multiple Biomarkers for the Prediction of First Major Cardiovascular Events and Death
Thomas J. Wang,Philimon Gona,Philimon Gona,Martin G. Larson,Martin G. Larson,Geoffrey H. Tofler,Daniel Levy,Daniel Levy,Christopher Newton-Cheh,Christopher Newton-Cheh,Paul F. Jacques,Nader Rifai,Jacob Selhub,Sander J. Robins,Sander J. Robins,Emelia J. Benjamin,Emelia J. Benjamin,Ralph B. D'Agostino,Ralph B. D'Agostino,Ramachandran S. Vasan,Ramachandran S. Vasan +20 more
TL;DR: The use of the 10 contemporary biomarkers that were studied adds only moderately to standard risk factors and only small increases in the ability to classify risk, as measured by the C statistic.