J
Jacob Wynne
Researcher at Emory University
Publications - 30
Citations - 2293
Jacob Wynne is an academic researcher from Emory University. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 6, co-authored 14 publications receiving 1711 citations. Previous affiliations of Jacob Wynne include Stanford University.
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Journal ArticleDOI
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
Aaron M. Newman,Scott V. Bratman,Jacqueline To,Jacob Wynne,Neville Eclov,Leslie A. Modlin,Chih Long Liu,Joel W. Neal,Heather A. Wakelee,Robert E. Merritt,Joseph B. Shrager,Billy W. Loo,Ash A. Alizadeh,Maximilian Diehn +13 more
TL;DR: It is envisioned that CAPP-Seq could be routinely applied clinically to detect and monitor diverse malignancies, thus facilitating personalized cancer therapy.
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Stereotactic ablative radiotherapy (SABR) for treatment of central and ultra-central lung tumors.
Aadel A. Chaudhuri,Chad Tang,Michael S. Binkley,Michelle Jin,Jacob Wynne,Rie von Eyben,Wendy Hara,Nicholas Trakul,Billy W. Loo,Maximilian Diehn +9 more
TL;DR: Patients with central and ultra-central lung tumors treated with SABR experienced few toxicities and good outcomes, similar to patients with peripheral lung tumors.
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A review on medical imaging synthesis using deep learning and its clinical applications.
TL;DR: This paper summarized the recent developments of deep learning-based methods in inter- and intra-modality image synthesis by listing and highlighting the proposed methods, study designs, and reported performances with related clinical applications on representative studies.
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Radiation, Immune Checkpoint Blockade and the Abscopal Effect: A Critical Review on Timing, Dose and Fractionation.
Zachary S. Buchwald,Jacob Wynne,Tahseen H. Nasti,Simeng Zhu,Waleed F. Mourad,Weisi Yan,Seema Gupta,Samir N. Khleif,Mohammad K. Khan +8 more
TL;DR: The known mechanistic data behind the immunostimulatory effects of radiation and how this is enhanced by immunotherapy are summarized and placed in a larger context of understanding T-cell exhaustion and the impact of immunotherapy on this phenotype.
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A phase I/II trial of 5-fraction stereotactic radiosurgery with 5-mm margins with concurrent temozolomide in newly diagnosed glioblastoma: primary outcomes.
Melissa Azoulay,Melissa Azoulay,Steven D. Chang,Iris C. Gibbs,Steven L. Hancock,Erqi L. Pollom,Griffith R. Harsh,John R. Adler,Ciara Harraher,Gordon Li,Melanie Hayden Gephart,Seema Nagpal,Reena Thomas,Lawrence Recht,Lisa R Jacobs,Leslie A. Modlin,Jacob Wynne,Kira Seiger,D.K. Fujimoto,Melissa Usoz,Rie von Eyben,Clara Y.H. Choi,Clara Y.H. Choi,Scott G. Soltys +23 more
TL;DR: The per-protocol MTD of 5-fraction SRS with 5-mm margins with concurrent temozolomide was 40 Gy in 5 fractions and were limited to grade 1-2 and did not statistically impact survival.