J
Jacqueline M. Kimmey
Researcher at University of California, Santa Cruz
Publications - 24
Citations - 1533
Jacqueline M. Kimmey is an academic researcher from University of California, Santa Cruz. The author has contributed to research in topics: Mycobacterium tuberculosis & Innate immune system. The author has an hindex of 10, co-authored 19 publications receiving 1142 citations. Previous affiliations of Jacqueline M. Kimmey include University of California, Los Angeles & University of California, San Diego.
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Journal ArticleDOI
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy
Robert O. Watson,Samantha L. Bell,Donna A. MacDuff,Jacqueline M. Kimmey,Elie J. Diner,Joanna Olivas,Russell E. Vance,Christina L. Stallings,Herbert W. Virgin,Jeffery S. Cox +9 more
TL;DR: It is reported that the cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is required for activating IFN production via the STING/TBK1/IRF3 pathway during M. tuberculosis and L. pneumophila infection of macrophages, whereas L. monocytogenes short-circuits this pathway by producing the STing agonist, c-di-AMP.
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Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection
Jacqueline M. Kimmey,Jeremy P. Huynh,Leslie A. Weiss,Sunmin Park,Amal Kambal,Jayanta Debnath,Herbert W. Virgin,Christina L. Stallings +7 more
TL;DR: It is shown that, contrary to expectation, autophagic capacity does not correlate with the outcome of M. tuberculosis infection in vivo, and ATG5 plays a unique role in protection against M.culosis by preventing PMN-mediated immunopathology.
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Discovery and characterization of a unique mycobacterial heme acquisition system.
Michael V. Tullius,Christine A. Harmston,Cedric P. Owens,Nicholas Chim,Robert P. Morse,Lisa M. McMath,Angelina Iniguez,Jacqueline M. Kimmey,Michael R. Sawaya,Julian P. Whitelegge,Marcus A. Horwitz,Celia W. Goulding +11 more
TL;DR: Key players of this heme uptake system were characterized including a secreted protein and two transmembrane proteins, all three specific to mycobacteria, and the crystal structure of the key heme carrier protein Rv0203 was found to have a unique fold.
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Bacterial Pathogens versus Autophagy: Implications for Therapeutic Interventions
TL;DR: This review evaluates the proposed roles for xenophagy in controlling bacterial infection, highlighting the concept that successful pathogens have evolved ways to subvert or exploit this defense, minimizing the actual effectiveness of xenophagic in innate immunity.
Journal ArticleDOI
Characterization of a Mycobacterium tuberculosis Nanocompartment and Its Potential Cargo Proteins
Heidi Contreras,Matthew S. Joens,Lisa M. McMath,Vincent P. Le,Michael V. Tullius,Jacqueline M. Kimmey,Neda Bionghi,Marcus A. Horwitz,James A. J. Fitzpatrick,Celia W. Goulding +9 more
TL;DR: It is shown by co-purification and electron microscopy that mycobacteria via Mt-Enc can encapsulate Mt-DyP, Mt-BfrB, and Mt-FolB, which may aid in detoxification of the local environment to ensure long term survival.