J
Jacquelyn Murphy
Researcher at Broad Institute
Publications - 8
Citations - 2200
Jacquelyn Murphy is an academic researcher from Broad Institute. The author has contributed to research in topics: Exome & Genome-wide association study. The author has an hindex of 7, co-authored 8 publications receiving 2003 citations.
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Journal ArticleDOI
The genetic architecture of type 2 diabetes
Christian Fuchsberger,Christian Fuchsberger,Jason Flannick,Jason Flannick,Tanya M. Teslovich,Anubha Mahajan,Vineeta Agarwala,Vineeta Agarwala,Kyle J. Gaulton,Clement Ma,Pierre Fontanillas,Loukas Moutsianas,Davis J. McCarthy,Manuel A. Rivas,John R. B. Perry,Xueling Sim,Thomas W. Blackwell,Neil Robertson,N. William Rayner,N. William Rayner,Pablo Cingolani,Adam E. Locke,Juan Fernandez Tajes,Heather M. Highland,Josée Dupuis,Josée Dupuis,Peter S. Chines,Cecilia M. Lindgren,Cecilia M. Lindgren,Christopher Hartl,Anne U. Jackson,Han Chen,Han Chen,Jeroen R. Huyghe,Martijn van de Bunt,Richard D. Pearson,Ashok Kumar,Ashok Kumar,Martina Müller-Nurasyid,Niels Grarup,Heather M. Stringham,Eric R. Gamazon,Jae-Hoon Lee,Yi Chen,Robert A. Scott,Jennifer E. Below,Peng Chen,Jinyan Huang,Min Jin Go,Michael L. Stitzel,Dorota Pasko,Stephen C. J. Parker,Tibor V. Varga,Todd Green,Nicola L. Beer,Aaron G. Day-Williams,Teresa Ferreira,Tasha E. Fingerlin,Momoko Horikoshi,Cheng Hu,Iksoo Huh,Mohammad Kamran Ikram,Mohammad Kamran Ikram,Bong-Jo Kim,Yongkang Kim,Young-Jin Kim,Min-Seok Kwon,Juyoung Lee,Selyeong Lee,Keng-Han Lin,Taylor J. Maxwell,Yoshihiko Nagai,Xu Wang,Ryan P. Welch,Joon Yoon,Weihua Zhang,Weihua Zhang,Nir Barzilai,Benjamin F. Voight,Bok-Ghee Han,Christopher P. Jenkinson,Christopher P. Jenkinson,Teemu Kuulasmaa,Johanna Kuusisto,Alisa K. Manning,Maggie C.Y. Ng,Nicholette D. Palmer,Beverley Balkau,Alena Stančáková,Hanna E. Abboud,Heiner Boeing,Vilmantas Giedraitis,Dorairaj Prabhakaran,Omri Gottesman,James Scott,Jason Carey,Phoenix Kwan,George B. Grant,Joshua D. Smith,Benjamin M. Neale,Benjamin M. Neale,Shaun Purcell,Shaun Purcell,Shaun Purcell,Adam S. Butterworth,Joanna M. M. Howson,Heung Man Lee,Yingchang Lu,Soo Heon Kwak,Wei Zhao,John Danesh,John Danesh,Vincent K. L. Lam,Kyong Soo Park,Danish Saleheen,Wing-Yee So,Claudia H. T. Tam,Uzma Afzal,David Aguilar,Rector Arya,Tin Aung,Tin Aung,Edmund Chan,Carmen Navarro,Ching-Yu Cheng,Ching-Yu Cheng,Domenico Palli,Adolfo Correa,Joanne E. Curran,Denis Rybin,Vidya S. Farook,Sharon P. Fowler,Barry I. Freedman,Michael Griswold,Daniel E. Hale,Pamela J. Hicks,Chiea Chuen Khor,Satish Kumar,Benjamin Lehne,Dorothée Thuillier,Wei-Yen Lim,Jianjun Liu,Jianjun Liu,Yvonne T. van der Schouw,Marie Loh,Marie Loh,Marie Loh,Solomon K. Musani,Sobha Puppala,William R. Scott,Loic Yengo,Sian-Tsung Tan,Sian-Tsung Tan,Herman A. Taylor,Farook Thameem,Gregory P. Wilson,Tien Yin Wong,Tien Yin Wong,Pål R. Njølstad,Jonathan C. Levy,Massimo Mangino,Lori L. Bonnycastle,Thomas Schwarzmayr,João Fadista,Gabriela L. Surdulescu,Christian Herder,Christopher J. Groves,Thomas Wieland,Jette Bork-Jensen,Ivan Brandslund,Cramer Christensen,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Alex S. F. Doney,Leena Kinnunen,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andrew Farmer,Liisa Hakaste,Dylan Hodgkiss,Jasmina Kravic,Valeriya Lyssenko,Mette Hollensted,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,Claes Ladenvall,Johanne Marie Justesen,Annemari Käräjämäki,Jennifer Kriebel,Wolfgang Rathmann,Lars Lannfelt,Torsten Lauritzen,Narisu Narisu,Allan Linneberg,Olle Melander,Lili Milani,Matt Neville,Marju Orho-Melander,Lu Qi,Qibin Qi,Qibin Qi,Michael Roden,Olov Rolandsson,Amy J. Swift,Anders Rosengren,Kathleen Stirrups,Andrew R. Wood,Evelin Mihailov,Christine Blancher,Mauricio O. Carneiro,Jared Maguire,Ryan Poplin,Khalid Shakir,Timothy Fennell,Mark A. DePristo,Martin Hrabé de Angelis,Panos Deloukas,Panos Deloukas,Anette P. Gjesing,Goo Jun,Goo Jun,Peter M. Nilsson,Jacquelyn Murphy,Robert C. Onofrio,Barbara Thorand,Torben Hansen,Torben Hansen,Christa Meisinger,Frank B. Hu,Bo Isomaa,Fredrik Karpe,Liming Liang,Annette Peters,Cornelia Huth,Stephen O'Rahilly,Colin N. A. Palmer,Oluf Pedersen,Rainer Rauramaa,Jaakko Tuomilehto,Veikko Salomaa,Richard M. Watanabe,Ann-Christine Syvänen,Richard N. Bergman,Dwaipayan Bharadwaj,Erwin P. Bottinger,Yoon Shin Cho,Giriraj R. Chandak,Juliana C.N. Chan,Kee Seng Chia,Mark J. Daly,Shah Ebrahim,Claudia Langenberg,Paul Elliott,Kathleen A. Jablonski,Donna M. Lehman,Weiping Jia,Ronald C.W. Ma,Toni I. Pollin,Manjinder S. Sandhu,Manjinder S. Sandhu,Nikhil Tandon,Philippe Froguel,Philippe Froguel,Inês Barroso,Inês Barroso,Yik Ying Teo,Eleftheria Zeggini,Ruth J. F. Loos,Kerrin S. Small,Janina S. Ried,Ralph A. DeFronzo,Harald Grallert,Benjamin Glaser,Andres Metspalu,Nicholas J. Wareham,Mark Walker,Eric Banks,Christian Gieger,Erik Ingelsson,Erik Ingelsson,Hae Kyung Im,Thomas Illig,Paul W. Franks,Paul W. Franks,Paul W. Franks,Gemma Buck,Joseph Trakalo,David Buck,Inga Prokopenko,Inga Prokopenko,Reedik Mägi,Lars Lind,Yossi Farjoun,Katharine R. Owen,Anna L. Gloyn,Konstantin Strauch,Tiinamaija Tuomi,Jaspal S. Kooner,Jaspal S. Kooner,Jong-Young Lee,Taesung Park,Peter Donnelly,Andrew D. Morris,Andrew D. Morris,Andrew T. Hattersley,Donald W. Bowden,Francis S. Collins,Gil Atzmon,Gil Atzmon,John C. Chambers,John C. Chambers,Tim D. Spector,Markku Laakso,Tim M. Strom,Graeme I. Bell,John Blangero,Ravindranath Duggirala,E. Shyong Tai,Gilean McVean,Craig L. Hanis,James G. Wilson,Mark Seielstad,Mark Seielstad,Timothy M. Frayling,James B. Meigs,Nancy J. Cox,Robert Sladek,Eric S. Lander,Stacey Gabriel,Noël P. Burtt,Karen L. Mohlke,Thomas Meitinger,Leif Groop,Leif Groop,Gonçalo R. Abecasis,Jose C. Florez,Jose C. Florez,Laura J. Scott,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Hyun Min Kang,Michael Boehnke,David Altshuler,David Altshuler,David Altshuler,Mark I. McCarthy +349 more
TL;DR: In this paper, the authors performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing for 12,940 individuals from five ancestry groups.
The genetic architecture of type 2 diabetes
Christian Fuchsberger,Jason Flannick,Tanya M. Teslovich,Anubha Mahajan,Vineeta Agarwala,Kyle J. Gaulton,Clement Ma,Pierre Fontanillas,Loukas Moutsianas,Davis J. McCarthy,Manuel A. Rivas,John R. B. Perry,Xueling Sim,Thomas W. Blackwell,Neil Robertson,N. William Rayner,Pablo Cingolani,Adam E. Locke,Juan Fernandez Tajes,Heather M. Highland,Josée Dupuis,Peter S. Chines,Cecilia M. Lindgren,Christopher Hartl,Anne U. Jackson,Han Chen,Jeroen R. Huyghe,Martijn van de Bunt,Richard D. Pearson,Ashok Kumar,Martina Mueller-Nurasyid,Niels Grarup,Heather M. Stringham,Eric R. Gamazon,Jae-Hoon Lee,Yi Chen,Robert A. Scott,Jennifer E. Below,Peng Chen,Jinyan Huang,Min Jin Go,Michael L. Stitzel,Dorota Pasko,Stephen C. J. Parker,Tibor V. Varga,Todd Green,Nicola L. Beer,Aaron G. Day-Williams,Teresa Ferreira,Tasha E. Fingerlin,Momoko Horikoshi,Cheng Hu,Iksoo Huh,Mohammad Kamran Ikram,Bong-Jo Kim,Yongkang Kim,Young-Jin Kim,Min-Seok Kwon,Juyoung Lee,Selyeong Lee,Keng-Han Lin,Taylor J. Maxwell,Yoshihiko Nagai,Xu Wang,Ryan P. Welch,Joon Yoon,Weihua Zhang,Nir Barzilai,Benjamin F. Voight,Bok-Ghee Han,Christopher P. Jenkinson,Teemu Kuulasmaa,Johanna Kuusisto,Alisa K. Manning,Maggie C.Y. Ng,Nicholette D. Palmer,Beverley Balkau,Alena Stančáková,Hanna E. Abboud,Heiner Boeing,Vilmantas Giedraitis,Dorairaj Prabhakaran,Omri Gottesman,James Scott,Jason Carey,Phoenix Kwan,George B. Grant,Joshua D. Smith,Benjamin M. Neale,Shaun Purcell,Adam S. Butterworth,Joanna M. M. Howson,Heung Man Lee,Yingchang Lu,Soo Heon Kwak,Wei Zhao,John Danesh,Vincent K. L. Lam,Kyong Soo Park,Danish Saleheen,Wing-Yee So,Claudia H. T. Tam,Uzma Afzal,David Aguilar,Rector Arya,Tin Aung,Edmund Chan,Carmen Navarro,Ching-Yu Cheng,Domenico Palli,Adolfo Correa,Joanne E. Curran,Denis Rybin,Vidya S. Farook,Sharon P. Fowler,Barry I. Freedman,Michael Griswold,Daniel E. Hale,Pamela J. Hicks,Chiea Chuen Khor,Satish Kumar,Benjamin Lehne,Dorothée Thuillier,Wei-Yen Lim,Jianjun Liu,Yvonne T. van der Schouw,Marie Loh,Solomon K. Musani,Sobha Puppala,William R. Scott,Loic Yengo,Sian-Tsung Tan,Herman A. Taylor,Farook Thameem,Gregory P. Wilson,Tien Yin Wong,Pål R. Njølstad,Jonathan C. Levy,Massimo Mangino,Lori L. Bonnycastle,Thomas Schwarzmayr,João Fadista,Gabriela L. Surdulescu,Christian Herder,Christopher J. Groves,Thomas Wieland,Jette Bork-Jensen,Ivan Brandslund,Cramer Christensen,Heikki A. Koistinen,Alex S. F. Doney,Leena Kinnunen,Tõnu Esko,Andrew Farmer,Liisa Hakaste,Dylan Hodgkiss,Jasmina Kravic,Valeriya Lyssenko,Mette Hollensted,Marit E. Jørgensen,Torben Jørgensen,Claes Ladenvall,Johanne Marie Justesen,Annemari Käräjämäki,Jennifer Kriebel,Wolfgang Rathmann,Lars Lannfelt,Torsten Lauritzen,Narisu Narisu,Allan Linneberg,Olle Melander,Lili Milani,Matt Neville,Marju Orho-Melander,Lu Qi,Qibin Qi,Michael Roden,Olov Rolandsson,Amy J. Swift,Anders Rosengren,Kathleen Stirrups,Andrew R. Wood,Evelin Mihailov,Christine Blancher,Mauricio O. Carneiro,Jared Maguire,Ryan Poplin,Khalid Shakir,Timothy R. Fennell,Mark A. DePristo,Martin Hrabé de Angelis,Panos Deloukas,Anette P. Gjesing,Goo Jun,Peter M. Nilsson,Jacquelyn Murphy,Robert C. Onofrio,Barbara Thorand,Torben Hansen,Christa Meisinger,Frank B. Hu,Bo Isomaa,Fredrik Karpe,Liming Liang,Annette Peters,Cornelia Huth,Stephen O'Rahilly,Colin N. A. Palmer,Oluf Pedersen,Rainer Rauramaa,Jaakko Tuomilehto,Veikko Salomaa,Richard M. Watanabe,Ann-Christine Syvänen,Richard N. Bergman,Dwaipayan Bharadwaj,Erwin P. Bottinger,Yoon Shin Cho,Giriraj R. Chandak,Juliana C.N. Chan,Kee Seng Chia,Mark J. Daly,Shah Ebrahim,Claudia Langenberg,Paul Elliott,Kathleen A. Jablonski,Donna M. Lehman,Weiping Jia,Ronald C.W. Ma,Toni I. Pollin,Manjinder S. Sandhu,Nikhil Tandon,Philippe Froguel,Inês Barroso,Yik Ying Teo,Eleftheria Zeggini,Ruth J. F. Loos,Kerrin S. Small,Janina S. Ried,Ralph A. DeFronzo,Harald Grallert,Benjamin Glaser,Andres Metspalu,Nicholas J. Wareham,Mark Walker,Eric Banks,Christian Gieger,Erik Ingelsson,Hae Kyung Im,Thomas Illig,Paul W. Franks,Gemma Buck,Joseph Trakalo,David Buck,Inga Prokopenko,Reedik Mägi,Lars Lind,Yossi Farjoun,Katharine R. Owen,Anna L. Gloyn,Konstantin Strauch,Tiinamaija Tuomi,Jaspal S. Kooner,Jong-Young Lee,Taesung Park,Peter Donnelly,Andrew D. Morris,Andrew T. Hattersley,Donald W. Bowden,Francis S. Collins,Gil Atzmon,John C. Chambers,Tim D. Spector,Markku Laakso,Tim M. Strom,Graeme I. Bell,John Blangero,Ravindranath Duggirala,E. Shyong Tai,Gilean McVean,Craig L. Hanis,James G. Wilson,Mark Seielstad,Timothy M. Frayling,James B. Meigs,Nancy J. Cox,Robert Sladek,Eric S. Lander,Stacey Gabriel,Noël P. Burtt,Karen L. Mohlke,Thomas Meitinger,Leif Groop,Gonçalo R. Abecasis,Jose C. Florez,Laura J. Scott,Andrew P. Morris,Hyun Min Kang,Michael Boehnke,David Altshuler,Mark I. McCarthy +300 more
TL;DR: Large-scale sequencing does not support the idea that lower-frequency variants have a major role in predisposition to type 2 diabetes, but most fell within regions previously identified by genome-wide association studies.
Journal ArticleDOI
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico
A. L. Williams Amy,A. L. Williams Amy,S. B R Jacobs Suzanne,Hortensia Moreno-Macías,Alicia Huerta-Chagoya,Claire Churchhouse,Carla Marquez-Luna,María José Gómez-Vázquez,N. P. Burtt Noël,Carlos A. Aguilar-Salinas,Clicerio Gonzalez-Villalpando,Jose C. Florez,Jose C. Florez,Lorena Orozco,Teresa Tusié-Luna,David Altshuler,David Altshuler,David Altshuler,Stephan Ripke,Stephan Ripke,Alisa K. Manning,Humberto García-Ortiz,Benjamin M. Neale,Benjamin M. Neale,David Reich,David Reich,Daniel O. Stram,Juan Carlos Fernández-López,Sandra Romero-Hidalgo,Nick Patterson,Christopher A. Haiman,Irma Aguilar-Delfín,Angélica Martínez-Hernández,Federico Centeno-Cruz,Elvia Mendoza-Caamal,Cristina Revilla-Monsalve,Sergio Islas-Andrade,Emilio J. Cordova,Eunice Rodríguez-Arellano,Xavier Soberón,J. C. Florez Jose,J. C. Florez Jose,M. A. González-Villalpando María Elena,Brian E. Henderson,Kristine R. Monroe,Lynne R. Wilkens,Laurence N. Kolonel,Loic Le Marchand,Laura Riba,M. A. Ordóñez-Sánchez María Luisa,Rosario Rodríguez-Guillén,Ivette Cruz-Bautista,Maribel Rodríguez-Torres,Linda Liliana Muñoz-Hernandez,Tamara Sáenz,Donají Gómez,Ulices Alvirde,Robert C. Onofrio,Wendy Brodeur,Diane Gage,Jacquelyn Murphy,Jennifer Franklin,Scott Mahan,Kristin G. Ardlie,Andrew Crenshaw,Wendy Winckler,Kay Prüfer,Michael V. Shunkov,Susanna Sawyer,Udo Stenzel,Janet Kelso,Monkol Lek,Monkol Lek,Sriram Sankararaman,Sriram Sankararaman,Daniel G. MacArthur,Daniel G. MacArthur,A.P. Derevianko,Svante Pääbo,Suzanne B.R. Jacobs,Shuba Gopal,James A. Grammatikos,Ian Smith,Kevin Bullock,Amy Deik,Amanda Souza,Kerry A. Pierce,Clary B. Clish,Timothy Fennell,Yossi Farjoun,Stacey Gabriel,Myron D. Gross,Mark A. Pereira,Mark Seielstad,Woon-Puay Koh,E. Shyong Tai,Jason Flannick,Jason Flannick,Pierre Fontanillas,Andrew D. Morris,Tanya M. Teslovich,Gil Atzmon,John Blangero,Donald W. Bowden,John C. Chambers,John C. Chambers,Yoon Shin Cho,Ravindranath Duggirala,Benjamin Glaser,Benjamin Glaser,Craig L. Hanis,Jaspal S. Kooner,Jaspal S. Kooner,Markku Laakso,Jong-Young Lee,Yik Ying Teo,Yik Ying Teo,James G. Wilson,Sobha Puppala,Vidya S. Farook,Farook Thameem,Hanna E. Abboud,Ralph A. DeFronzo,Christopher P. Jenkinson,Donna M. Lehman,Joanne E. Curran,Maria L. Cortes,C. González-Villalpando Clicerio,L. Orozco Lorena +128 more
TL;DR: Analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism and an archaic genome sequence indicated that the risk haplotype introgressed into modern humans via admixture with Neanderthals.
Journal ArticleDOI
Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
Anubha Mahajan,Xueling Sim,Hui Jin Ng,Alisa K. Manning,Manuel A. Rivas,Heather M. Highland,Adam E. Locke,Niels Grarup,Hae Kyung Im,Pablo Cingolani,Jason Flannick,Pierre Fontanillas,Christian Fuchsberger,Kyle J. Gaulton,Tanya M. Teslovich,N. William Rayner,Neil R. Robertson,Nicola L. Beer,Jana K. Rundle,Jette Bork-Jensen,Claes Ladenvall,Christine Blancher,David Buck,Gemma Buck,Noël P. Burtt,Stacey Gabriel,Anette P. Gjesing,Christopher J. Groves,Mette Hollensted,Jeroen R. Huyghe,Anne U. Jackson,Goo Jun,Johanne Marie Justesen,Massimo Mangino,Jacquelyn Murphy,Matt J. Neville,Robert C. Onofrio,Kerrin S. Small,Heather M. Stringham,Ann-Christine Syvänen,Joseph Trakalo,Gonçalo R. Abecasis,Graeme I. Bell,John Blangero,Nancy J. Cox,Ravindranath Duggirala,Craig L. Hanis,Mark Seielstad,James G. Wilson,Cramer Christensen,Ivan Brandslund,Rainer Rauramaa,Gabriela L. Surdulescu,Alex S. F. Doney,Lars Lannfelt,Allan Linneberg,Bo Isomaa,Tiinamaija Tuomi,Marit E. Jørgensen,Torben Jørgensen,Johanna Kuusisto,Matti Uusitupa,Veikko Salomaa,Tim D. Spector,Andrew D. Morris,Colin N. A. Palmer,Francis S. Collins,Karen L. Mohlke,Richard N. Bergman,Erik Ingelsson,Lars Lind,Jaakko Tuomilehto,Torben Hansen,Richard M. Watanabe,Inga Prokopenko,Josée Dupuis,Fredrik Karpe,Leif Groop,Markku Laakso,Oluf Pedersen,Jose C. Florez,Andrew P. Morris,David Altshuler,James B. Meigs,Michael Boehnke,Mark I. McCarthy,Cecilia M. Lindgren,Anna L. Gloyn +87 more
TL;DR: In this article, the authors analyzed exome-array data from up to 33,231 non-diabetic individuals of European ancestry and identified multiple coding variants in G6PC2 (p.Val219Leu, p.His177Tyr, and p.Tyr207Ser) influencing FG levels, conditionally independent of each other and the non-coding GWAS signal.
Journal ArticleDOI
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
Alisa K. Manning,Alisa K. Manning,Heather M. Highland,Heather M. Highland,Jessica A. Gasser,Xueling Sim,Taru Tukiainen,Taru Tukiainen,Pierre Fontanillas,Niels Grarup,Manuel A. Rivas,Anubha Mahajan,Adam E. Locke,Pablo Cingolani,Tune H. Pers,Ana Viñuela,Ana Viñuela,Andrew A. Brown,Andrew A. Brown,Ying Wu,Jason Flannick,Jason Flannick,Christian Fuchsberger,Eric R. Gamazon,Kyle J. Gaulton,Kyle J. Gaulton,Hae Kyung Im,Tanya M. Teslovich,Thomas W. Blackwell,Jette Bork-Jensen,Noël P. Burtt,Yuhui Chen,Todd Green,Christopher Hartl,Hyun Min Kang,Ashok Kumar,Ashok Kumar,Claes Ladenvall,Clement Ma,Loukas Moutsianas,Richard D. Pearson,John R. B. Perry,John R. B. Perry,John R. B. Perry,N. William Rayner,N. William Rayner,N. William Rayner,Neil R. Robertson,Neil R. Robertson,Laura J. Scott,Martijn van de Bunt,Martijn van de Bunt,Johan G. Eriksson,Antti Jula,Seppo Koskinen,Terho Lehtimäki,Aarno Palotie,Aarno Palotie,Aarno Palotie,Olli T. Raitakari,Olli T. Raitakari,Suzanne B.R. Jacobs,Jennifer Wessel,Audrey Y. Chu,Robert A. Scott,Mark O. Goodarzi,Christine Blancher,Gemma Buck,David Buck,Peter S. Chines,Stacey Gabriel,Anette P. Gjesing,Christopher J. Groves,Mette Hollensted,Jeroen R. Huyghe,Anne U. Jackson,Goo Jun,Johanne Marie Justesen,Massimo Mangino,Jacquelyn Murphy,Matt J. Neville,Robert C. Onofrio,Kerrin S. Small,Heather M. Stringham,Joseph Trakalo,Eric Banks,Jason Carey,Mauricio O. Carneiro,Mark A. DePristo,Yossi Farjoun,Timothy Fennell,Jacqueline I. Goldstein,Jacqueline I. Goldstein,George B. Grant,Martin Hrabé de Angelis,Jared Maguire,Benjamin M. Neale,Benjamin M. Neale,Ryan Poplin,Shaun Purcell,Shaun Purcell,Shaun Purcell,Thomas Schwarzmayr,Khalid Shakir,Joshua D. Smith,Tim M. Strom,Thomas Wieland,Jaana Lindström,Ivan Brandslund,Cramer Christensen,Gabriela L. Surdulescu,Timo A. Lakka,Alex S. F. Doney,Peter M. Nilsson,Nicholas J. Wareham,Claudia Langenberg,Tibor V. Varga,Paul W. Franks,Paul W. Franks,Paul W. Franks,Olov Rolandsson,Anders Rosengren,Vidya S. Farook,Farook Thameem,Sobha Puppala,Satish Kumar,Donna M. Lehman,Christopher P. Jenkinson,Joanne E. Curran,Daniel E. Hale,Sharon P. Fowler,Rector Arya,Ralph A. DeFronzo,Hanna E. Abboud,Ann-Christine Syvänen,Pamela J. Hicks,Nicholette D. Palmer,Maggie C.Y. Ng,Donald W. Bowden,Barry I. Freedman,Tõnu Esko,Reedik Mägi,Lili Milani,Evelin Mihailov,Andres Metspalu,Narisu Narisu,Leena Kinnunen,Lori L. Bonnycastle,Amy J. Swift,Dorota Pasko,Andrew R. Wood,João Fadista,Toni I. Pollin,Nir Barzilai,Gil Atzmon,Benjamin Glaser,Barbara Thorand,Konstantin Strauch,Annette Peters,Michael Roden,Martina Müller-Nurasyid,Liming Liang,Jennifer Kriebel,Thomas Illig,Harald Grallert,Christian Gieger,Christa Meisinger,Lars Lannfelt,Solomon K. Musani,Michael Griswold,Herman A. Taylor,Gregory A Wilson,Adolfo Correa,Heikki Oksa,William R. Scott,Uzma Afzal,Sian-Tsung Tan,Marie Loh,Marie Loh,Marie Loh,John C. Chambers,John C. Chambers,John C. Chambers,Jobanpreet Sehmi,Jaspal S. Kooner,Benjamin Lehne,Yoon Shin Cho,Jong-Young Lee,Bok-Ghee Han,Annemari Käräjämäki,Qibin Qi,Qibin Qi,Lu Qi,Lu Qi,Jinyan Huang,Frank B. Hu,Olle Melander,Marju Orho-Melander,Jennifer E. Below,David Aguilar,Tien Yin Wong,Jianjun Liu,Jianjun Liu,Chiea Chuen Khor,Kee Seng Chia,Wei-Yen Lim,Ching-Yu Cheng,Edmund Chan,E. Shyong Tai,Tin Aung,Allan Linneberg,Allan Linneberg,Bo Isomaa,Thomas Meitinger,Tiinamaija Tuomi,Liisa Hakaste,Jasmina Kravic,Marit E. Jørgensen,Torsten Lauritzen,Panos Deloukas,Kathleen Stirrups,Kathleen Stirrups,Katharine R. Owen,Andrew Farmer,Timothy M. Frayling,Stephen O'Rahilly,Mark Walker,Jonathan C. Levy,Dylan Hodgkiss,Andrew T. Hattersley,Teemu Kuulasmaa,Alena Stančáková,Inês Barroso,Inês Barroso,Dwaipayan Bharadwaj,Juliana C.N. Chan,Giriraj R. Chandak,Mark J. Daly,Peter Donnelly,Peter Donnelly,Shah Ebrahim,Paul Elliott,Tasha E. Fingerlin,Philippe Froguel,Cheng Hu,Weiping Jia,Ronald C.W. Ma,Gilean McVean,Taesung Park,Dorairaj Prabhakaran,Manjinder S. Sandhu,Manjinder S. Sandhu,James Scott,Robert Sladek,Nikhil Tandon,Yik Ying Teo,Eleftheria Zeggini,Richard M. Watanabe,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Y. Antero Kesäniemi,Matti Uusitupa,Tim D. Spector,Veikko Salomaa,Rainer Rauramaa,Colin N. A. Palmer,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko,Andrew D. Morris,Richard N. Bergman,Francis S. Collins,Lars Lind,Erik Ingelsson,Jaakko Tuomilehto,Fredrik Karpe,Leif Groop,Torben Jørgensen,Torben Jørgensen,Torben Hansen,Torben Hansen,Oluf Pedersen,Johanna Kuusisto,Gonçalo R. Abecasis,Graeme I. Bell,John Blangero,Nancy J. Cox,Ravindranath Duggirala,Mark Seielstad,Mark Seielstad,James G. Wilson,Josée Dupuis,Samuli Ripatti,Samuli Ripatti,Craig L. Hanis,Jose C. Florez,Karen L. Mohlke,James B. Meigs,James B. Meigs,Markku Laakso,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Michael Boehnke,David Altshuler,Mark I. McCarthy,Mark I. McCarthy,Anna L. Gloyn,Anna L. Gloyn,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren +312 more
TL;DR: The allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis is extended and bidirectional effects of variants within the pleckstrin homology domain ofAKT2 are demonstrated.