Jadine Paw

TL;DR: A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function.

TL;DR: Using computational predictions combined with traditional quantitative experiments, 100 proteins whose deficiency alters mitochondrial biogenesis and inheritance in Saccharomyces cerevisiae are identified and characterized mutants with subtle mitochondrial defects whose phenotypes were undetected by high-throughput methods.

TL;DR: An activity-dependent physical and functional interaction between CaN and GABAA receptors is both necessary and sufficient for inducing LTD at CA1 individual inhibitory synapses.

TL;DR: It is found that more than one-third (140) of the 399 examinable WGD paralog pairs were epistatic under standard laboratory conditions and that additional cases of epistasis became obvious only under media conditions designed to induce cellular stress, suggesting that many epistatic relationships remain unresolved.

TL;DR: This work built a set of donor strains, called Barcoders, with unique bar codes that can be systematically transferred to any S. cerevisiae collection, and generated a collection of bar-coded 'decreased abundance by mRNA perturbation' (DAmP) loss-of-function strains comprising 87.1% of all essential yeast genes.