Jae Hyun Lee

TL;DR: These magnetism-engineered iron oxide (MEIO) nanoprobes, when conjugated with antibodies, showed enhanced magnetic resonance imaging (MRI) sensitivity for the detection of cancer markers compared with probes currently available and could enhance the ability to visualize other biological events critical to diagnostics and therapeutics.

TL;DR: This Letter demonstrates a significant increase in the efficiency of magnetic thermal induction by nanoparticles and finds that the therapeutic efficacy of these nanoparticles is superior to that of a common anticancer drug.

TL;DR: The development of a synthetically controlled magnetic nanocrystal model system that correlates the nanoscale tunabilities in terms of size, magnetism, and induced nuclear spin relaxation processes led to the development of high-performance Nanocrystal-antibody probe systems for the diagnosis of breast cancer cells via magnetic resonance imaging.

TL;DR: This study finds that high performance in vivo MR diagnosis of cancer is achievable by utilizing improved and multifunctional material properties of iron oxide nanocrystal probes.

TL;DR: An overview of recent breakthroughs in the development of new synthetic MNP probes with which the sensitive and target-specific observation of biological events at the molecular and cellular levels is possible is presented.