J
Jae-Woo Lee
Researcher at University of California, San Francisco
Publications - 78
Citations - 6220
Jae-Woo Lee is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Lung injury & Mesenchymal stem cell. The author has an hindex of 33, co-authored 73 publications receiving 5201 citations. Previous affiliations of Jae-Woo Lee include Beth Israel Deaconess Medical Center & Federal University of Rio de Janeiro.
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Journal ArticleDOI
Intrapulmonary Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Survival and Attenuates Endotoxin-Induced Acute Lung Injury in Mice
TL;DR: Treatment with intrapulmonary MSC markedly decreases the severity of endotoxin-induced acute lung injury and improves survival in mice.
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Antibacterial Effect of Human Mesenchymal Stem Cells Is Mediated in Part from Secretion of the Antimicrobial Peptide LL‐37
Anna Krasnodembskaya,Yuanlin Song,Xiaohui Fang,Naveen Gupta,Vladimir B. Serikov,Jae-Woo Lee,Michael A. Matthay +6 more
TL;DR: Human bone marrow‐derived MSCs possess direct antimicrobial activity, which is mediated in part by the secretion of human cathelicidin hCAP‐18/ LL‐37, analysis of expression of major antimicrobial peptides indicated.
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Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial
Jennifer G. Wilson,Kathleen D. Liu,Hanjing Zhuo,Lizette Caballero,Melanie McMillan,Xiaohui Fang,Katherine Cosgrove,Rosemary Vojnik,Carolyn S. Calfee,Jae-Woo Lee,Angela J. Rogers,Joseph E. Levitt,Jeanine P. Wiener-Kronish,Ednan K. Bajwa,Andrew D. Leavitt,David H. McKenna,B. Taylor Thompson,Michael A. Matthay +17 more
TL;DR: A single intravenous infusion of allogeneic, bone marrow-derived human MSCs was well tolerated in nine patients with moderate-to-severe ARDS, and this phase 1 trial has proceeded to phase 2 testing of M SCs for moderate to severe ARDS with a primary focus on safety and secondary outcomes including respiratory, systemic, and biological endpoints.
Journal ArticleDOI
Allogeneic human mesenchymal stem cells for treatment of E. Coli endotoxin-induced acute lung injury in an ex vivo perfused human lung
TL;DR: In this paper, the authors tested the therapeutic capacity of human MSCs to restore alveolar epithelial fluid transport and lung fluid balance from acute lung injury (ALI) in an ex vivo perfused human lung preparation injured by E. coli endotoxin.
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Postoperative Pulmonary Complications, Early Mortality, and Hospital Stay Following Noncardiothoracic Surgery: A Multicenter Study by the Perioperative Research Network Investigators
Ana Fernandez-Bustamante,Gyorgy Frendl,Juraj Sprung,Daryl J. Kor,Bala Subramaniam,Ricardo Martinez Ruiz,Jae-Woo Lee,William G. Henderson,Angela Moss,Nitin Mehdiratta,Megan M. Colwell,Karsten Bartels,Kerstin Kolodzie,Jadelis Giquel,Marcos F. Vidal Melo +14 more
TL;DR: Patients with 1 or more PPCs, even mild, had significantly increased early postoperative mortality, intensive care unit (ICU) admission, and ICU/hospital length of stay, despite current protective ventilation practices.