The chemistry of recently isolated naturally occurring quinazolinone alkaloids

Direct and rapid heating by microwave irradiation in combination with sealed vessel processing in many cases enables reactions to be carried out in a fraction of the time generally required using conventional conditions. This makes microwave chemistry an ideal tool for rapid reaction scouting and optimization of conditions, allowing very rapid progress through hypotheses–experiment–results iterations. The speed at which multiple variations of reaction conditions can be performed allows a morning discussion of “What should we try?” to become an after-lunch discussion of “What were the results” Not surprisingly, therefore, many scientists both in academia and industry have turned to microwave synthesis as a front-line methodology for their projects. In this review, more than 220 published examples of microwave-assisted synthetic organic transformations from the 2004 to 2008 literature are discussed. An additional ca. 500 reaction schemes are presented in the Electronic Supplementary Material, providing the reader with an overall number of ca. 930 references in this fast-moving and exciting field.

Controlled microwave heating in modern organic synthesis: highlights from the 2004–2008 literature

In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives.

Efficient synthesis of mono- and disubstituted 2,3-dihydroquinazolin-4(1H)-ones using KAl(SO4)2·12H2O as a reusable catalyst in water and ethanol

The 4(3H)-quinazolinone is a frequently encountered heterocycle with broad applications including antimalarial, antitumor, anticonvulsant, fungicidal, antimicrobial, and anti-inflammatory. The current review article will briefly outline the new routes and strategies for the synthesis of valuable 4(3H)-quinazolinones.

Recent advances in 4(3H)-quinazolinone syntheses

Microwave-assisted one-pot synthesis of 2,3-disubstituted 3H-quinazolin-4-ones

Efficient Synthesis of a Benzo[b]furan Building Block

A practical synthesis of the previously unreported 5-formylbenzo[b]furan-2-carbonitrile (VIII) is described.

Efficient Synthesis of a Benzo[b]furan Building Block.

A practical synthesis of 2,3-disubstituted 3 H -quinazolin-4-ones 1 with broad chemistry scope is described. The key step is the microwave promoted one-pot, two-step reaction sequence combining anthranilic acids, carboxylic acids, and amines providing efficient access to this important class of heterocycles.

Jaekyoo Lee

Papers

Microwave-assisted one-pot synthesis of 2,3-disubstituted 3H-quinazolin-4-ones

Efficient Synthesis of a Benzo[b]furan Building Block

Efficient Synthesis of a Benzo[b]furan Building Block.

Microwave-Assisted One-Pot Synthesis of 2,3-Disubstituted 3H-Quinazolin-4-ones.