Jagadish M. Deshpande

TL;DR: The status of environmental surveillance used by the Global Polio Eradication Initiative is summarized, the rationale for ES is provided, examples of ES methods and findings are given, and how these data are used to achieve poliovirus eradication are summarized.

TL;DR: It is shown that high population density and poor sanitation cause persistence by not only facilitating transmission of poliovirus but also severely compromising the efficacy of the trivalent vaccine, and switching to monovalent vaccine may finally interrupt virus transmission.

TL;DR: In this article, a high-potency monovalent oral type 1 poliovirus vaccine (mOPV1) was developed in 2005 to tackle persistent Poliovirus transmission in the last remaining infected countries.

TL;DR: A randomised, double-blind, controlled trial to assess the immunogenicity of a novel bivalent types 1 and 3 oral poliovirus vaccine and the superiority of monovalent type 2 OPV over trivalent OPV, and the non-inferiority of bivalent vaccine compared with mopV1 and mOPV3.

TL;DR: Controversy over vaccine choice for polio eradication can be reconciled by effective combined use of IPV and Sabin together, and IPV in OPV-vaccinated individuals boosts intestinal mucosal immunity.