J
Jakob Linseisen
Researcher at German Cancer Research Center
Publications - 295
Citations - 25283
Jakob Linseisen is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: European Prospective Investigation into Cancer and Nutrition & Population. The author has an hindex of 84, co-authored 251 publications receiving 23040 citations. Previous affiliations of Jakob Linseisen include Helmholtz Zentrum München.
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Journal ArticleDOI
Haplotype-based analysis of common variation in the acetyl-CoA carboxylase α gene and breast cancer risk: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition
Olga M. Sinilnikova,James McKay,Sean V. Tavtigian,Federico Canzian,Deepika DeSilva,Carine Biessy,Stéphanie Monnier,Laure Dossus,Catherine Boillot,Lydie Gioia,David J. Hughes,Majken K. Jensen,Kim Overvad,Anne Tjønneland,Anja Olsen,Françoise Clavel-Chapelon,Véronique Chajès,Virginie Joulin,Jakob Linseisen,Jenny Chang-Claude,Heiner Boeing,Stephan Dahm,Antonia Trichopoulou,Dimitrios Trichopoulos,Maria Koliva,Kay-Tee Khaw,Sheila Bingham,Naomi E. Allen,Timothy J. Key,Domenico Palli,Salvatore Panico,Franco Berrino,Rosario Tumino,Paolo Vineis,H. Bas Bueno-de-Mesquita,Petra H.M. Peeters,Carla H. van Gils,Eiliv Lund,Guillem Pera,José Ramón Quirós,Miren Dorronsoro,Carmen Martinez Garcia,María José Tormo,Eva Ardanaz,Göran Hallmans,Per Lenner,Göran Berglund,Jonas Manjer,Elio Riboli,Gilbert M. Lenoir,Rudolf Kaaks,Rudolf Kaaks +51 more
TL;DR: An effect on overall risk of breast cancer in homozygous carriers of one common haplotype is found and a possible role of the ACC-α common sequence variants in susceptibility to breast cancer is suggested, which should be considered as preliminary and evaluated in larger independent studies.
Journal ArticleDOI
Association of hydroxyprostaglandin dehydrogenase 15-(NAD) ( HPGD ) variants and colorectal cancer risk
Bernd Frank,Birgit Hoeft,Michael Hoffmeister,Jakob Linseisen,Lutz P. Breitling,Jenny Chang-Claude,Hermann Brenner,Alexandra Nieters,Alexandra Nieters +8 more
TL;DR: The data do not support the previously reported associations of HPGD tagSNPs and risk of CRC, and none of the haplotypes was found to be associated with CRC, colon or rectal cancers.
Journal ArticleDOI
Determination of nasal and oropharyngeal microbiomes in a multicenter population-based study – findings from Pretest 1 of the German National Cohort
Manas K. Akmatov,Nadine Koch,Marius Vital,Wolfgang Ahrens,Dieter Flesch-Janys,Julia Fricke,Julia Fricke,Anja Gatzemeier,Halina Greiser,Kathrin Günther,Thomas Illig,Rudolf Kaaks,Bastian Krone,Andrea A. Kühn,Jakob Linseisen,Christine Meisinger,Karin B. Michels,Susanne Moebus,Alexandra Nieters,Nadia Obi,A. Schultze,Julia Six-Merker,Dietmar H. Pieper,Frank Pessler +23 more
TL;DR: It is suggested that nasal and oropharyngeal swabbing are highly feasible methods for human population-based studies that include the characterization of microbial community structures in these important ecological niches, and that self-collection of nasal swabs at home can be used to reduce cost and resources needed, particularly when serial measurements are to be taken.
Journal ArticleDOI
Polymorphisms in heterocyclic aromatic amines metabolism-related genes are associated with colorectal adenoma risk
Monika Eichholzer,Sabine Rohrmann,Aline Barbir,Silke Hermann,Birgit Teucher,Rudolf Kaaks,Jakob Linseisen +6 more
TL;DR: Polymorphisms in NAT1, NAT2, and GSTA1 are related to colorectal adenoma risk in this German cohort, and homozygous carriers of the A allele of rs3957357 (GSTA1), i.e., those with a decreased enzyme activity, had a decreased risk of coloreCTalAdenoma.
Journal Article
n6/n3 hypothesis and allergies: biologically plausible, but not confirmed
Iris Kompauer,Hans Demmelmair,Berthold Koletzko,Gabriele Bolte,Jakob Linseisen,Joachim Heinrich +5 more
TL;DR: It is concluded that the n6/n3- ratio hypothesis is not confirmed although biological plausible, and the dietary intake of certain fatty acids might contribute to the development of atopic diseases like allergic rhinitis and asthma.