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Jaleal S. Sanjak

Researcher at University of California, Irvine

Publications -  15
Citations -  409

Jaleal S. Sanjak is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 6, co-authored 9 publications receiving 285 citations.

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Evolutionary genomics of grape (Vitis vinifera ssp. vinifera) domestication.

TL;DR: The population history of grapes is estimated and it is confirmed that clonal propagation leads to the accumulation of recessive deleterious mutations but without decreasing fitness, which solves three ongoing mysteries about plant domestication.
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Evidence of directional and stabilizing selection in contemporary humans.

TL;DR: It is demonstrated that the genetic variants associated with several traits, including age at first birth in females and body-mass index in males, are also associated with reproductive success, and phenotypic evidence suggests that stabilizing selection is widespread and relatively weak in comparison with estimates from other species.
Posted ContentDOI

The Evolutionary Genomics of Grape (Vitis vinifera ssp. vinifera) Domestication

TL;DR: The population history of grapes was estimated and it was found that grape accessions contained 5.2% more deleterious variants than wild individuals, and these were more often in a heterozygous state, than their wild ancestors.
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A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets

TL;DR: It is demonstrated that the model of gene action, relating genotype to phenotype, has a qualitative effect on several relevant aspects of the population genetic architecture of a complex trait, including genetic variance component partitioning across the allele frequency spectrum and the power of statistical tests.
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Revised Annotations, Sex-Biased Expression, and Lineage-Specific Genes in the Drosophila melanogaster Group

TL;DR: In this article, the authors provide revised gene models for D. ananassae, D. yakuba, and D. simulans, which include untranslated regions and empirically verified intron-exon boundaries, as well as ortholog groups identified using a fuzzy reciprocal-best-hit blast comparison.