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James B. Potash

Researcher at Johns Hopkins University

Publications -  218
Citations -  28304

James B. Potash is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Bipolar disorder & Genome-wide association study. The author has an hindex of 68, co-authored 207 publications receiving 24016 citations. Previous affiliations of James B. Potash include Johns Hopkins University School of Medicine & University of Iowa Hospitals and Clinics.

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The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.

Rafael A. Irizarry, +13 more
- 01 Feb 2009 - 
TL;DR: Methylation changes in cancer are at sites that vary normally in tissue differentiation, consistent with the epigenetic progenitor model of cancer, which proposes that epigenetic alterations affecting tissue-specific differentiation are the predominant mechanism by which epigenetic changes cause cancer.
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

S. Hong Lee, +405 more
- 01 Sep 2013 - 
TL;DR: Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Naomi R. Wray, +262 more
- 26 Apr 2018 - 
TL;DR: A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia.
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Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

Pamela Sklar, +192 more
- 01 Oct 2011 - 
TL;DR: An analysis of all 11,974 bipolar disorder cases and 51,792 controls confirmed genome-wide significant evidence of association for CACNA1C and identified a new intronic variant in ODZ4, and a pathway comprised of subunits of calcium channels enriched in bipolar disorder association intervals was identified.