J
James Claffey
Researcher at University College Dublin
Publications - 33
Citations - 746
James Claffey is an academic researcher from University College Dublin. The author has contributed to research in topics: Titanocene dichloride & Fulvene. The author has an hindex of 18, co-authored 33 publications receiving 712 citations.
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Journal ArticleDOI
Synthesis, Cytotoxicity and Antibacterial Studies of p-Methoxybenzyl-Substituted and Benzyl-Substituted N-Heterocyclic Carbene-Silver Complexes
Siddappa A. Patil,James Claffey,Anthony Deally,Megan Hogan,Brendan Gleeson,Luis Miguel Menéndez Méndez,Helge Müller-Bunz,Francesca Paradisi,Matthias Tacke +8 more
TL;DR: In this paper, the N-heterocyclic carbene (NHC) precursors were synthesized from the reaction of 1H-imidazole (1a), 4,5-dichloro-1H-IMIDZO (1b) with p-methoxybenzyl bromide (2) and benzyl-bromide(5).
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Novel organotin antibacterial and anticancer drugs
Brendan Gleeson,James Claffey,Daniel Ertler,Megan Hogan,Helge Müller-Bunz,Francesca Paradisi,Denise Wallis,Matthias Tacke +7 more
TL;DR: In this article, the reaction of 6-(methoxyphenyl) fulvene with tin tetrachloride yielded the benzyl-substituted derivatives bis-(p-methoxybenzyl)cyclopentadienyl] tin(IV) dichloride (4a), bis-[(p-N,N-dimethylaminobenzyl] carbamide]-tin(IV), and bis-(3,4-dimethoxymynyl) carbamide-cyclopentadiene]-tin-decoyl
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Oxali-titanocene Y: a potent anticancer drug.
TL;DR: The in vitro and ex vivo experiments showed that renal cell cancer is the prime target for this novel class of titanocenes, but there is significant activity against ovarian, prostate, cervical, lung, colon, and breast cancers as well.
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Proliferative and anti-proliferative effects of titanium- and iron-based metallocene anti-cancer drugs
Anne Vessières,Marie-Aude Plamont,Claude Cabestaing,James Claffey,Sandra Dieckmann,Megan Hogan,Helge Müller-Bunz,Katja Strohfeldt,Matthias Tacke +8 more
TL;DR: In this paper, two Titanocene tamoxifen derivatives, Titanocene Y and Titanocene K, were tested on breast cancer cells and they showed a significant dose dependent cytotoxic effect.
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Analyses of Titanocenes in the spheroid-based cellular angiogenesis assay.
TL;DR: Titanocene dichloride and Titanocene Y combines both favourable anticancer activities and seems to be the drug candidate of choice for further optimisation.