Author
James D. Hoeschele
Other affiliations: Michigan State University, University of Tennessee, University of Michigan
Bio: James D. Hoeschele is an academic researcher from Oak Ridge National Laboratory. The author has contributed to research in topics: Cisplatin & Platinum. The author has an hindex of 18, co-authored 31 publications receiving 1831 citations. Previous affiliations of James D. Hoeschele include Michigan State University & University of Tennessee.
Topics: Cisplatin, Platinum, Ligand (biochemistry), Denticity, Chemistry
Papers
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TL;DR: A wide variety of Platinum(II) complexes have been investigated for antitumor activity against Sarcoma 180 in Swiss white female mice as mentioned in this paper, and the results showed that only neutral complexes exhibit activity while charged species are inactive and relatively nontoxic.
531 citations
TL;DR: The binding of cis(c)- and trans(t)-Pt(NH3)2Cl2 to DNA at platinum/DNA-nucleotide ratios (Ri) of 0.1 or less has been studied by means of radioactive 195mPt-labeled compounds, suggesting that both compounds should bind to DNA under biological conditions.
204 citations
TL;DR: Forty-one compounds of the general formula V v OLL', where L is a tridentate ligand (HSALIMH = [4-(2-salicylideneaminato)ethyl]imidazole; H 2 SHED = N-(saliclyideneaminaato)-N'-(2-hydroxyethyl)ethylenediamine; HENSAL = n-(salisticylideniaminato)-ethylENiamine) and L' is a bidentate, noninnocent ligand as mentioned in this paper ).
Abstract: Forty-one compounds of the general formula V v OLL', where L is a tridentate ligand (HSALIMH = [4-(2-salicylideneaminato)ethyl]imidazole; H 2 SHED = N-(salicylideneaminato)-N'-(2-hydroxyethyl)ethylenediamine; HENSAL = N-(salicylideneaminato)ethylenediamine) and L' is a bidentate, noninnocent ligand (e.g., catechol (H 2 CAT), pyrogallol (H 2 PYR), or salicylhyddroxamic acid (H 3 SHI) have been prepared and spectroscopically characterized
140 citations
TL;DR: A wide range of asymmetric Schiff base ligands containing primary amine functions can be prepared in one step and in high yield by the reaction of VO(OEt) 3 with salicylaldehyde and the appropriate diamine.
Abstract: A wide range of asymmetric Schiff base ligands containing primary amine functions can be prepared in one step and in high yield by the reaction of VO(OEt) 3 with salicylaldehyde and the appropriate diamine. The resulting VO 2 L complexes contain tridentate ligands with phenolate, imine, and amine coordination to the dioxovanadium(V) complex ion. An X-ray structure of one compound ([VO 2 (1,2-pnSAL), 5A, where 1,2-pnSAL=1(N-salicylideneamina)-2-aminopropane) demonstrates that it is a dimer in the solid state with a V 2 O 4 score
105 citations
TL;DR: Gel filtration of tissue extracts after either in vivo or in vitro treatment with DDP showed that Pt was bound to a molecular species with properties characteristic of MT, verified by atomic absorption spectrophotometry and polyacrylamide gel electrophoresis assays.
104 citations
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2,719 citations
TL;DR: Recently, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs as mentioned in this paper.
Abstract: The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer, but new platinum agents have been very slow to enter the clinic. Recently, however, there has been a surge of activity, based on a great deal of mechanistic information, aimed at developing nonclassical platinum complexes that operate via mechanisms of action distinct from those of the approved drugs. The use of nanodelivery devices has also grown, and many different strategies have been explored to incorporate platinum warheads into nanomedicine constructs. In this Review, we discuss these efforts to create the next generation of platinum anticancer drugs. The introduction provides the reader with a brief overview of the use, development, and mechanism of action of the approved platinum drugs to provide the context in which more recent research has flourished. We then describe approaches that explore nonclassical platinum(II) complexes with trans geometry or with a monofunctional coordination mode, polynuclea...
1,682 citations
1,671 citations
TL;DR: Preclinical data that has clinical relevance generated over the past five years of platinating agents, including cisplatin, carboplatin, and oxaliplatin are focused on.
1,370 citations
TL;DR: Protein Nanoparticle Interactions: Opportunities and Challenges
Abstract: Protein Nanoparticle Interactions: Opportunities and Challenges Morteza Mahmoudi,* Iseult Lynch, Mohammad Reza Ejtehadi, Marco P. Monopoli, Francesca Baldelli Bombelli, and Sophie Laurent National Cell Bank, Pasteur Institute of Iran, Tehran, Iran Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran School of Chemistry and Chemical Biology & Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland Department of Physics, Sharif University of Technology, Tehran, Iran School of Pharmacy, UEA, Norwich Research Park, Norwich,U.K. Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Avenue Maistriau 19, B-7000 Mons, Belgium
1,214 citations