Author
James E. Murphy
Bio: James E. Murphy is an academic researcher. The author has contributed to research in topics: Digitalis & Aglycone. The author has an hindex of 2, co-authored 4 publications receiving 29 citations.
Topics: Digitalis, Aglycone, Digitalis lanata
Papers
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TL;DR: A previously unreported cardioactive glycoside has been isolated from the leaves of D. lanata and found to be closely related to digoxin and gitoxin.
Abstract: A previously unreported cardioactive glycoside has been isolated from the leaves of D. lanata and found to be closely related to digoxin and gitoxin. Both the glycoside and its aglycone are relatively water soluble.
19 citations
TL;DR: A new glycoside, the monodigitoxoside of gitoxigenin, has been isolated from D. lanata and procedures for its isolation and characterization are given.
Abstract: A new glycoside, the monodigitoxoside of gitoxigenin, has been isolated from D. lanata. Procedures for its isolation and characterization are given.
8 citations
TL;DR: A procedure is given for determining the amount of impurities resent in digitalis glycosides and some of their preparations based on the fluorescence produced with a solution of propylene glycol and hydrochloric acid.
Abstract: A procedure is given for determining the amount of impurities resent in digitalis glycosides and some of their preparations based on the fluorescence produced with a solution of propylene glycol and hydrochloric acid.
2 citations
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TL;DR: This chapter discusses the sugars of the cardiac glycosides, which are a group of plant materials arbitrarily named because of their specific digitalis-like effect on the heart muscle that fall into two types depending upon the aglycon.
Abstract: Publisher Summary This chapter discusses the sugars of the cardiac glycosides, which are a group of plant materials arbitrarily named because of their specific digitalis-like effect on the heart muscle. Their physiological activity is primarily dependent on the nature of the aglycon rather than on the carbohydrate component. These drugs usually consist of mixtures that are found in quite dissimilar plants, the Apocynaceae and Asclepiadaceae being especially rich in them. Chemically, the cardiac glycosides are steroid derivatives that fall into two types depending upon the aglycon. The cardiac glycosides thus defined do not all exhibit digitalis-like properties. The corresponding glycosides occur in the same plants but have not been isolated in pure form. These substances are classified with the digitaloid lactones because of analogous structures, even when they exhibit no digitalis-like activity.
81 citations
TL;DR: The pflanzlichen Cardenolid-Glykoside sind als Hauptvertreter der digitalis-artig wirksamen Stoffe wegen ihrer praktischen Bedeutung in der lgedizin schon relativ frfih and eingehend untersucht worden as discussed by the authors.
Abstract: Die pflanzlichen Cardenolid-Glykoside sind als Hauptvertreter der digitalis-artig wirksamen Stoffe wegen ihrer praktischen Bedeutung in der lgedizin schon relativ frfih und eingehend untersucht worden. Pregnan-Glykoside sind erst in den letzten Jahren wiederholt in Pflanzen gefunden worden. Beide Gruppen besitzen in ihrem chemischen Aufbau gewisse gemeinsame Zfige, dutch die sie sieh yon anderen natfirlichen Glykosiden unterscheiden. Hier wird zusammenfassend fiber einige dieser Besonderheiten berichtet, die ihre Ursache vermutlich in einer etwas abweichenden Biogenese haben. Um deut~ lich zu machen, worin diese Unterschiede bestehen, werden die beiden Stoffgruppen zuerst mit anderen nattirlichen Glykosiden vergliehen. 3. Die verschiedenen Typen natiidicher O-Glykoside
69 citations
TL;DR: Gitoxigenin (I) wurde auf mikrobiologischem Wege (12β-Hydroxylierung durch Fusarium lini (BOLLEY)) in Diginatigenin ubergefuhrt.
Abstract: Gitoxigenin (I) wurde auf mikrobiologischem Wege (12β-Hydroxylierung durch Fusarium lini (BOLLEY)) in Diginatigenin ubergefuhrt. Damit sind sowohl das 5β-Carden-(20:22)-olid-Gerust als auch Hydroxylgruppen in 3β-, 14β- und 16β-Stellung bewiesen, sowie das Vorliegen einer 12β-standigen HO-Gruppe weitgehend gesichert. Diginatigenin wird deshalb Formel IV erteilt.
31 citations
29 citations
TL;DR: In this paper, the authors described the isolation, characterisation and chemical investigation of the cardiac glycosides of the dried leaves of Isoplexis isabelliana (WEBB) MASF.
Abstract: The isolation, characterisation and chemical investigation of the cardiac glycosides of the dried leaves of Isoplexis isabelliana (WEBB) MASF. are described. 7 glucosides B, D, E, J (monoside), K, M, and 1 (monoside) could be obtained in homogenous form, 3 others were mixtures (“A” = A1 + A2, “C” = C1 + C2, and “G” = G + K). The substances B (gluco-evatromonoside), D (cheiroside A), E (digitoxigenin-glucosido-6-deoxyglucoside), J (digitoxigenin glucoside), and M (digitalinum verum) could be identified with known substances. The new glycosides are derived from 3 genins: digitoxigenin, uzarigenin, and xysmalogenin, which are directly bound to one of the following sugars: 6-deoxyglucose, 2-O-acetyl-6-deoxy-D-glucose, 2,6-dideoxy-D-arabinohexose (= D-canarose), and 2,6-dideoxy-D-ribohexose (= D-digitoxose), terminated by a glucose unit. –Canarobiose, a new crystalline disaccharide of D-glucose and D-canarose, has also been obtained. –Apart from these cardiac glycosides 3 C21-steroids have been isolated (in addition to the 2 known genins γ-digiprogenin and purpnigenin), and their structures elucidated. The presence of 2 sapogenins has been detected.
18 citations