J
James E. Robinson
Researcher at Tulane University
Publications - 161
Citations - 20287
James E. Robinson is an academic researcher from Tulane University. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 59, co-authored 150 publications receiving 19297 citations. Previous affiliations of James E. Robinson include University Medical Center New Orleans & New York University.
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Journal ArticleDOI
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
Peter D. Kwong,Richard T. Wyatt,James E. Robinson,Raymond W. Sweet,Joseph Sodroski,Wayne A. Hendrickson,Wayne A. Hendrickson +6 more
TL;DR: The structure reveals a cavity-laden CD4–gp120 interface, a conserved binding site for the chemokine receptor, evidence for a conformational change upon CD4 binding, the nature of a CD4-induced antibody epitope, and specific mechanisms for immune evasion.
Journal ArticleDOI
The antigenic structure of the HIV gp120 envelope glycoprotein
Richard T. Wyatt,Peter D. Kwong,Elizabeth Desjardins,Raymond W. Sweet,James E. Robinson,Wayne A. Hendrickson,Joseph Sodroski +6 more
TL;DR: The spatial organization of conserved neutralization epitopes on gp120 is described, using epitope maps in conjunction with the X-ray crystal structure of a ternary complex that includes a gp120 core, CD4 and a neutralizing antibody.
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CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.
Alexandra Trkola,Tatjana Dragic,James Arthos,James M. Binley,William C. Olson,Graham P. Allaway,Cecilia Cheng-Mayer,James E. Robinson,Paul J. Maddon,John P. Moore +9 more
TL;DR: CD4 binding, although not absolutely necessary for the gp120–CCR-5 interaction, greatly increases its efficiency, and interference with HIV-1 binding to one or both of its receptors (CD4 and CCR-5) may be an important mechanism of virus neutralization.
Journal ArticleDOI
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
Peter D. Kwong,Peter D. Kwong,Michael L. Doyle,Michael L. Doyle,David J. Casper,Claudia Cicala,Stephanie A. Leavitt,Shahzad Majeed,Shahzad Majeed,Tavis D. Steenbeke,Miro Venturi,Irwin Chaiken,Michael Fung,Hermann Katinger,Paul W. I. H. Parren,James E. Robinson,Donald Van Ryk,Liping Wang,Dennis R. Burton,Ernesto Freire,Richard T. Wyatt,Richard T. Wyatt,Joseph Sodroski,Wayne A. Hendrickson,Wayne A. Hendrickson,James Arthos +25 more
TL;DR: It is shown that recognition by receptor-binding-site antibodies induces conformational change, and conformational masking enables HIV-1 to maintain receptor binding and simultaneously to resist neutralization.
Journal ArticleDOI
Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies
Barton F. Haynes,Judith A. Fleming,E. William St. Clair,Herman Katinger,Gabriela Stiegler,Renate Kunert,James E. Robinson,Richard M. Scearce,Kelly Plonk,Herman F. Staats,Thomas L. Ortel,Hua-Xin Liao,S. Munir Alam +12 more
TL;DR: It is demonstrated that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin, which may have important implications for generating effective neutralizing antibody responses by using HIV- 1 vaccines.