J
James E. Sylvester
Researcher at University of Pennsylvania
Publications - 27
Citations - 2351
James E. Sylvester is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Ribosomal RNA & Ribosomal DNA. The author has an hindex of 20, co-authored 27 publications receiving 2306 citations. Previous affiliations of James E. Sylvester include Tufts University & Drexel University.
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Journal ArticleDOI
The homologue of the Duchenne locus is defective in X-linked muscular dystrophy of dogs.
Barry J. Cooper,Nena J. Winand,Hansell H. Stedman,Beth A. Valentine,Eric P. Hoffman,Louis M. Kunkel,Marion-Oronzi Scott,Kenneth H. Fischbeck,Joe N. Kornegay,Roger J. Avery,James R. Williams,Roy D. Schmickel,James E. Sylvester +12 more
TL;DR: It is reported here that dogs with CXMD faithfully mimic the phenotype of Duchenne muscular dystrophy and that they lack the Duchennes gene transcript and its protein product, dystrophin.
Journal ArticleDOI
Cloning of the breakpoint of an X;21 translocation associated with Duchenne muscular dystrophy.
Peter N. Ray,Bonnie Belfall,Catherine Duff,Cairine Logan,Vanora Kean,Margaret Thompson,James E. Sylvester,Jerome L. Gorski,Roy D. Schmickel,Ronald G. Worton +9 more
TL;DR: In this article, the authors used rRNA sequences as probes to clone the region spanning the translocation breakpoint, which was then used to detect a restriction fragment length polymorphism (RFLP) which was closely linked to the DMD gene and uncovers chromosomal deletions in some male DMD patients.
Journal ArticleDOI
Variation among human 28S ribosomal RNA genes.
Iris L. Gonzalez,Jerome L. Gorski,Thomas J. Campen,D. J. Dorney,Jeanne Erickson,James E. Sylvester,Roy D. Schmickel +6 more
TL;DR: The complete 5025-base sequence of the human 28S rRNA gene is reported and the rapid divergence rates of variable regions in the ribosomal gene may permit answers to the question of time of separation of closely related species.
Journal ArticleDOI
Complete Sequence of the 43-kb Human Ribosomal DNA Repeat: Analysis of the Intergenic Spacer
TL;DR: The sequence of the complete IGS reveals a collection of sequence motifs that can be correlated with functions known or expected to reside in the rDNA repeat: modulation of transcription, recombination, initiation of DNA replication, and chromosomal organization.
Journal ArticleDOI
Human ribosomal RNA genes: orientation of the tandem array and conservation of the 5' end.
Ronald G. Worton,Joanne Sutherland,James E. Sylvester,Huntington F. Willard,Sharon Bodrug,Ian Dubé,Catherine Duff,Vanora Kean,Peter N. Ray,Roy D. Schmickel +9 more
TL;DR: Restriction maps, sequence data, and gene mapping studies demonstrate that the rRNA genes are transcribed in a telomere-to-centromere direction, and the 5' end of the cluster and the adjacent non-rDNA sequences are conserved on the five pairs of chromosomes.