James F. Leckman

TL;DR: Data from 105 subjects support the construct, convergent, and discriminant validity of the instrument, and indicate that the YGTSS is a promising instrument for the assessment of tic severity in children, adolescents and adults.

TL;DR: The CY-BOCS yields reliable and valid subscale and total scores for obsessive-compulsive symptom severity in children and adolescents with OCD and may be influenced by age of the child and the hazards associated with integrating data from parental and patient sources.

TL;DR: It is shown that it is possible to make lifetime best estimate diagnoses reliably among both interviewed and noninterviewed individuals for most diagnostic categories and that diagnoses based on interview data alone are an adequate substitute for best estimate prescriptions based on all available information in a limited number of diagnostic categories.

TL;DR: The relatives of female probands with obsessive-compulsive disorder were more likely to have tics, and the relatives of Probands with early onset were at higher risk for both obsessive-Compulsive disorder and tics.

TL;DR: Findings support the association of rare SLITRK1 sequence variants with TS by identifying a frameshift mutation and two independent occurrences of the identical variant in the binding site for microRNA hsa-miR-189.