抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

Approximate Riemann Solvers, Parameter Vectors, and Difference Schemes

We present an overview of the lattice Boltzmann method (LBM), a parallel and efficient algorithm for simulating single-phase and multiphase fluid flows and for incorporating additional physical complexities. The LBM is especially useful for modeling complicated boundary conditions and multiphase interfaces. Recent extensions of this method are described, including simulations of fluid turbulence, suspension flows, and reaction diffusion systems.

Lattice boltzmann method for fluid flows

Preface 1. Introduction 2. Conservation laws and differential equations 3. Characteristics and Riemann problems for linear hyperbolic equations 4. Finite-volume methods 5. Introduction to the CLAWPACK software 6. High resolution methods 7. Boundary conditions and ghost cells 8. Convergence, accuracy, and stability 9. Variable-coefficient linear equations 10. Other approaches to high resolution 11. Nonlinear scalar conservation laws 12. Finite-volume methods for nonlinear scalar conservation laws 13. Nonlinear systems of conservation laws 14. Gas dynamics and the Euler equations 15. Finite-volume methods for nonlinear systems 16. Some nonclassical hyperbolic problems 17. Source terms and balance laws 18. Multidimensional hyperbolic problems 19. Multidimensional numerical methods 20. Multidimensional scalar equations 21. Multidimensional systems 22. Elastic waves 23. Finite-volume methods on quadrilateral grids Bibliography Index.

https://depts.washington.edu/clawpack/book2/sample.pdf

Finite Volume Methods for Hyperbolic Problems

Solutions in the large for nonlinear hyperbolic systems of equations

algebras. The w*-closure of the pure states of one of these algebras is the set of all states of the algebra. This is not the first example of a C*-algebra whose set of pure states is not closed, cf. [7]. In ?3 we classify the irreducible representations of uniformly hyperfinite algebras according to unitary equivalence. In ??4 and 5 we study certain representations of uniformly hyperfinite algebras.

On a certain class of operator algebras

We describe a three-dimensional front tracking algorithm, discuss its numerical implementation, and present studies to validate the correctness of this approach. Based on the results of the two-dimensional computations, we expect three-dimensional front tracking to significantly improve computational efficiencies for problems dominated by discontinuities. In some cases, for which the interface computations display considerable numerical sensitivity, we expect a greatly enhanced capability.

James Glimm

Papers

Solutions in the large for nonlinear hyperbolic systems of equations

On a certain class of operator algebras

Three-Dimensional Front Tracking

Decay of Solutions of Systems of Nonlinear Hyperbolic Conservation Laws

Type I C ∗ -Algebras