J
James H. McKerrow
Researcher at University of Montana
Publications - 398
Citations - 26005
James H. McKerrow is an academic researcher from University of Montana. The author has contributed to research in topics: Proteases & Cysteine protease. The author has an hindex of 86, co-authored 390 publications receiving 24157 citations. Previous affiliations of James H. McKerrow include San Francisco VA Medical Center & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Cysteine proteases of parasitic organisms
Mohammed Sajid,James H. McKerrow +1 more
TL;DR: In this paper, the authors highlight recent research on the Papain-like and asparaginyl-endopeptidase classes of cysteine proteases and re-examine them in light of the diversity uncovered within parasitic organisms.
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Protease inhibitors targeting coronavirus and filovirus entry
Yanchen Zhou,Punitha Vedantham,Kai Lu,Juliet Agudelo,Ricardo Carrion,Jerritt Nunneley,Dale L. Barnard,Stefan Pöhlmann,James H. McKerrow,Adam R. Renslo,Graham Simmons +10 more
TL;DR: It is demonstrated that viral spread and pathogenesis of SARS-CoV is driven by serine rather than cysteine proteases and can be effectively prevented by camostat, while vinyl sulfone-based inhibitors are excellent lead candidates for Ebola virus therapeutics.
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Tumour necrosis factor α restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice
P Amiri,Richard M. Locksley,Tristram G. Parslow,M Sadick,E Rector,D Ritter,James H. McKerrow,James H. McKerrow +7 more
TL;DR: It is reported that the immunoregulatory cytokine tumour necrosis factor α is necessary and sufficient to reconstitute granuloma formation in schistosome-infected SCID mice and that the parasite has adapted so successfully to its host that it uses a host-derived immuno-regulatory protein as a signal for replication and transmission.
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The Proteases and Pathogenicity of Parasitic Protozoa
TL;DR: Detailed studies of parasite-derived proteases have led to model systems for the study of parasite gene regulation, parasite metabolism, and the host-parasite interplay, and in some instances, proteases appear to be promising targets for the development of new antiparasitic chemotherapy.
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Proteases in parasitic diseases
TL;DR: This review focuses on the direct role of proteases in disease pathogenesis and well-characterized examples of the roles proteases play in pathogenesis include their involvement in invasion of the host by parasite migration through tissue barriers, degradation of hemoglobin and other blood proteins, immune evasion, and activation of inflammation.