J
James J. Christensen
Researcher at Brigham Young University
Publications - 289
Citations - 18351
James J. Christensen is an academic researcher from Brigham Young University. The author has contributed to research in topics: Aqueous solution & Membrane. The author has an hindex of 57, co-authored 289 publications receiving 17715 citations. Previous affiliations of James J. Christensen include University of Sheffield.
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MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Jeffrey A. Engelman,Kreshnik Zejnullahu,Tetsuya Mitsudomi,Youngchul Song,Courtney Hyland,Joon Oh Park,Neal I. Lindeman,Christopher-Michael Gale,Xiaojun Zhao,James J. Christensen,Takayuki Kosaka,Alison J. Holmes,Andrew M. Rogers,Federico Cappuzzo,Tony Mok,Charles Lee,Bruce E. Johnson,Lewis C. Cantley,Pasi A. Jänne +18 more
TL;DR: It is proposed that MET amplification may promote drug resistance in other ERBB-driven cancers as well after it was found that amplification of MET causes gefitinib resistance by driving ERBB3 (HER3)–dependent activation of PI3K, a pathway thought to be specific to EGFR/ERBB family receptors.
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Thermodynamic and kinetic data for cation-macrocycle interaction
Reed M. Izatt,Jerald S. Bradshaw,Steven A. Nielsen,John D. Lamb,James J. Christensen,Debabrata Sen +5 more
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Sites and thermodynamic quantities associated with proton and metal ion interaction with ribonucleic acid, deoxyribonucleic acid, and their constituent bases, nucleosides, and nucleotides.
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The Synthesis and Ion Bindings of Synthetic Multidentate Macrocyclic Compounds.
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Calorimetric titration study of the interaction of several uni- and bivalent cations with 15-crown-5, 18-crown-6, and two isomers of dicyclohexo-18-crown-6 in aqueous solution at 25.degree.C and .mu. = 0.1
Reed M. Izatt,R. E. Terry,Barry L. Haymore,Lee D. Hansen,N. K. Dalley,A. G. Avondet,James J. Christensen +6 more