Showing papers by "James J. Collins published in 1989"

Mortality patterns among workers exposed to acrylamide.

Abstract: A cohort of 8854 men, 2293 of whom were exposed to acrylamide, was examined from 1925 to 1983 for mortality. This cohort consisted of four plant populations in two countries: the United States and The Netherlands. No statistically significant excess of all-cause or cause-specific mortality was found among acrylamide workers. Analysis by acrylamide exposure levels showed no trend of increased risk of mortality from several cancer sites. These results do not support the hypothesis that acrylamide is a human carcinogen.

Mortality patterns among men exposed to methyl methacrylate.

Abstract: A cohort of 2,671 men, 1561 of whom were exposed to methyl methacrylate, was observed from 1951 to 1983 for mortality. This cohort consisted of men from two plants. This study utilizes detailed exposure estimates and smoking status to evaluate mortality patterns. We find no statistically significant excess all-cause or cause-specific mortality. Analysis of dose of methyl methacrylate with several cancer sites showed no trend. Men exposed to high levels of methyl methacrylate had cancer rates similar to those for men not exposed in the workplace, as well as for other men in the US population. An earlier epidemiology study reported a significant excess of colorectal cancer among persons exposed to several substances including methyl methacrylate. Our study results and results from animal studies do not support the hypothesis that methyl methacrylate is a human carcinogen.