J
James J. Collins
Researcher at Massachusetts Institute of Technology
Publications - 700
Citations - 105255
James J. Collins is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Synthetic biology & Population. The author has an hindex of 151, co-authored 669 publications receiving 89476 citations. Previous affiliations of James J. Collins include Baylor College of Medicine & University at Albany, SUNY.
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Cellular decision making and biological noise: from microbes to mammals.
TL;DR: It is proposed that cellular decision making is one of at least three key processes underlying development at various scales of biological organization.
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Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis
TL;DR: It is shown that sublethal levels of bactericidal antibiotics induce mutagenesis, resulting in heterogeneous increases in the minimum inhibitory concentration for a range of antibiotics, irrespective of the drug target.
Cellular Decision Making and Biological Noise: From Microbes to Mammals
TL;DR: In this paper, the authors review several examples of cellular decision-making from viruses, bacteria, yeast, lower metazoans and mammals, highlighting the role of regulatory network structure and molecular noise.
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Dispersing biofilms with engineered enzymatic bacteriophage
Timothy K. Lu,James J. Collins +1 more
TL;DR: This work demonstrates the feasibility and benefits of using engineered enzymatic bacteriophage to reduce bacterial biofilms and the applicability of synthetic biology to an important medical and industrial problem.
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Metabolite-enabled eradication of bacterial persisters by aminoglycosides
Kyle R. Allison,Mark P. Brynildsen,Mark P. Brynildsen,James J. Collins,James J. Collins,James J. Collins +5 more
TL;DR: It is shown that specific metabolic stimuli enable the killing of both Gram-negative and Gram-positive bacterial persisters with aminoglycosides, and this approach can improve the treatment of chronic infections in a mouse urinary tract infection model.