J
James J. Collins
Researcher at Massachusetts Institute of Technology
Publications - 700
Citations - 105255
James J. Collins is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Synthetic biology & Population. The author has an hindex of 151, co-authored 669 publications receiving 89476 citations. Previous affiliations of James J. Collins include Baylor College of Medicine & University at Albany, SUNY.
Papers
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Journal ArticleDOI
Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics
TL;DR: This work highlights applications of synthetic biology in vaccine development, molecular diagnostics, and cell-based therapeutics, emphasizing technologies approved for clinical use or in active clinical trials.
Journal ArticleDOI
Eradicating Bacterial Persisters with Combinations of Strongly and Weakly Metabolism-Dependent Antibiotics
TL;DR: Insight into metabolism-dependent bactericidal antibiotic efficacy is leveraged to design antibiotic combinations that sterilize both metabolically active and persister cells, while minimizing the antibiotic concentrations required.
Book
Understanding Tolowa Histories: Western Hegemonies and Native American Responses
TL;DR: In this article, Collins explores the linguistic and political dynamics of place-claiming and expropriation as well as the relation between otherness and subjugation of the Native Tolowa.
Journal ArticleDOI
Low level occupational benzene exposure and hematological parameters
Gerard M H Swaen,Ludovic G. P. M. van Amelsvoort,Johannes J. Twisk,Etienne Verstraeten,Ronald Slootweg,James J. Collins,Carol J. Burns +6 more
TL;DR: This study does not indicate that workers exposed to low benzene concentrations are at an increased risk for hematological effects and analysis modeling the continuous exposure effect relationship showed similar findings.
Creating Single-Copy Genetic Circuits
Kyeong Rok Choi,Jeffrey C. Way,Pamela A. Silver,Jeong Wook Lee,Andras Gyoergy,David Cameron,Nora C. Pyenson,Domitilla Del Vecchio,James J. Collins +8 more
TL;DR: The design parameters developed here provide important guidance for future efforts to convert functional multi-copy gene circuits into optimized single-copy circuits for practical, real-world use.