J
James J. Tomasek
Researcher at University of Oklahoma Health Sciences Center
Publications - 65
Citations - 9611
James J. Tomasek is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Myofibroblast & Wound healing. The author has an hindex of 37, co-authored 64 publications receiving 8846 citations. Previous affiliations of James J. Tomasek include University at Albany, SUNY & University of Oklahoma.
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Myofibroblasts and mechano-regulation of connective tissue remodelling
TL;DR: It is clear that the understanding of the myofibroblast — its origins, functions and molecular regulation — will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.
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Alpha-Smooth Muscle Actin Expression Upregulates Fibroblast Contractile Activity
TL;DR: An increased alpha-SMA expression is sufficient to enhance fibroblast contractile activity, with the use of silicone substrates of different stiffness degrees.
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Transforming Growth Factor-β1 Promotes the Morphological and Functional Differentiation of the Myofibroblast
TL;DR: It is demonstrated that TGF-beta1 promoted a dose-dependent increase in the generation of contractile force in myofibroblasts and a concomitant increased in the expression of alpha-sm actin, and that this enhancement occurred prior to, and independent of, alpha-Sm actin expression.
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Fibroblast contraction occurs on release of tension in attached collagen lattices: Dependency on an organized actin cytoskeleton and serum
TL;DR: It is demonstrated that fibroblasts can develop tension in an attached collagen lattice and that upon release of tension the fibro Blasts undergo contraction resulting in a rapid contraction of the collagen lattices.
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Mechanical properties of the extracellular matrix influence fibronectin fibril assembly in vitro.
TL;DR: The results suggest that the features of fibronectin required for fibroblasts in collagen gels is similar to those required by cells cultured on a planar substratum, indicating that stress fiber formation and contractile force transmission is not dependent on the presence of fibronsectin fibrils.