J
James M. Downey
Researcher at University of South Alabama
Publications - 385
Citations - 30419
James M. Downey is an academic researcher from University of South Alabama. The author has contributed to research in topics: Ischemic preconditioning & Ischemia. The author has an hindex of 91, co-authored 381 publications receiving 29506 citations. Previous affiliations of James M. Downey include Aventis Pharma & University of South Florida.
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Journal ArticleDOI
Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart.
TL;DR: Adenosine released during the preconditioning occlusion stimulates cardiac A 1 receptors, which leaves the heart protected against infarction even after the adenosine has been withdrawn.
Journal ArticleDOI
Preconditioning the Myocardium: From Cellular Physiology to Clinical Cardiology
Derek M. Yellon,James M. Downey +1 more
TL;DR: The understanding of the mechanisms associated with preconditioning are unravelled can look forward to the development of new therapeutic agents with novel mechanisms of action that can supplement current treatment options for patients threatened with acute myocardial infarction.
Journal ArticleDOI
Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.
Tilley Pain,X.-M. Yang,Stuart D. Critz,Yankun Yue,Atsushi Nakano,Guang S. Liu,Gerd Heusch,Michael V. Cohen,James M. Downey +8 more
TL;DR: Mito KATP channels are not the end effectors of protection, but rather their opening before ischemia generates free radicals that trigger entrance into a preconditioned state and activation of kinases, indicating that diazoxide triggers protection through free radicals.
Journal ArticleDOI
Xanthine oxidase as a source of free radical damage in myocardial ischemia.
David E. Chambers,Dale A. Parks,Guy Patterson,Ranjan S. Roy,Joe M. McCord,S. Yoshida,Loren F. Parmley,James M. Downey +7 more
TL;DR: The infarcts in the allopurinol and superoxide dismutase groups were significantly smaller than those in the control groups, and the xanthine oxidase/xanthine dehydrogenase content of dog myocardium was determined.
Journal ArticleDOI
Preconditioning protects ischemic rabbit heart by protein kinase C activation.
TL;DR: Activation of protein kinase C with 4 beta-phorbol 12-myristate 13-acetate (PMA) or with 1-oleyl-2-acetyl glycerol (OAG) mimicked preconditioning in buffer-perfused hearts, which blocked protection from ischemic preconditionsing in isolated heart.