J
James M. Schaeffer
Researcher at Merck & Co.
Publications - 125
Citations - 11891
James M. Schaeffer is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Somatostatin. The author has an hindex of 48, co-authored 117 publications receiving 11350 citations. Previous affiliations of James M. Schaeffer include Boston Children's Hospital & Netherlands Cancer Institute.
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Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
TL;DR: A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.
Journal ArticleDOI
Immunolocalization of estrogen receptor β in the mouse brain: Comparison with estrogen receptor α
Sudha W. Mitra,Elena Hoskin,Joel B. Yudkovitz,Lisset Pear,Hilary A. Wilkinson,Shinji Hayashi,Donald W. Pfaff,Sonoko Ogawa,Susan P. Rohrer,James M. Schaeffer,Bruce S. McEwen,Stephen E. Alves +11 more
TL;DR: The development of an ERβ-selective antibody that cross-reacts with mouse, rat, and human ERβ protein and its use to determine the distribution of ERβ in the murine brain is reported.
Journal ArticleDOI
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans
Doris F. Cully,Demetrios K. Vassilatis,Ken K. Liu,Philip S. Paress,Lex H.T. Van der Ploeg,James M. Schaeffer,Joseph P. Arena +6 more
TL;DR: The electrophysiological and structural properties of these proteins indicate that they are new members of the ligand-gated ion channel superfamily.
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Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor.
Lois E.H. Smith,Wei Shen,Carole A. Perruzzi,Shay Soker,Fumi Kinose,Xianghong Xu,Gregory S. Robinson,Samuel E. Driver,Joyce Bischoff,Bei Zhang,James M. Schaeffer,Donald R. Senger +11 more
TL;DR: Findings establish an essential role for IGF-1 in angiogenesis and demonstrate a new target for control of retinopathy, and explain why diabetic Retinopathy initially increases with the onset of insulin treatment.
Journal ArticleDOI
Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry
Susan P. Rohrer,Elizabeth T. Birzin,Ralph T. Mosley,Scott C. Berk,Steven M. Hutchins,Dong-Ming Shen,Yusheng Xiong,Edward C. Hayes,Rupa M. Parmar,Forrest Foor,Sudha W. Mitra,Sylvia J. Degrado,Min Shu,John M. Klopp,Sheng-Jian Cai,Allan D. Blake,Wanda W.-S. Chan,Alex Pasternak,Lihu Yang,Arthur A. Patchett,Roy G. Smith,Kevin T. Chapman,James M. Schaeffer +22 more
TL;DR: The availability of high-affinity, subtype-selective agonists for each of the somatostatin receptors provides a direct approach to defining their physiological functions, including inhibition of glucagon release from mouse pancreatic alpha cells and mediator of insulin secretion from pancreatic beta cells.