J
James Marvin Veal
Researcher at Durham University
Publications - 80
Citations - 4213
James Marvin Veal is an academic researcher from Durham University. The author has contributed to research in topics: Oxindole & Cancer. The author has an hindex of 30, co-authored 78 publications receiving 3966 citations. Previous affiliations of James Marvin Veal include Research Triangle Park & GlaxoSmithKline.
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Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor†
Philip A. Harris,Amogh Boloor,Mui Cheung,Rakesh Kumar,Renae M. Crosby,Ronda G. Davis-Ward,Andrea H. Epperly,Kevin Hinkle,Robert N. Hunter,Jennifer H. Johnson,Victoria B. Knick,Christopher P. Laudeman,Deirdre K. Luttrell,Robert A. Mook,Robert T. Nolte,Sharon K. Rudolph,Szewczyk Jerzy Ryszard,Anne T. Truesdale,James Marvin Veal,Liping Wang,Jeffrey A. Stafford +20 more
TL;DR: The key steps starting from an initial screening hit leading to the discovery of pazopanib are described, a potent pan-VEGF receptor (VEGFR) inhibitor under clinical development for renal-cell cancer and other solid tumors.
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A Nucleic Acid Triple Helix Formed by a Peptide Nucleic Acid-DNA Complex
TL;DR: Hydrogen bonds between the DNA backbone and the Hoogsteen PNA backbone explain the observation that polypyrimidine PNA sequences form highly stable 21 PNA-DNA complexes, expanding the number of known stable helical forms that nucleic acids can adopt.
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Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.
H. N. Bramson,J. Corona,Stephen T. Davis,Scott Howard Dickerson,Mark P. Edelstein,Stephen V. Frye,Robert T. Gampe,Philip A. Harris,A.M. Hassell,William D. Holmes,Robert N. Hunter,Karen Lackey,B. Lovejoy,Michael Joseph Luzzio,Valerie G. Montana,Warren J. Rocque,David W. Rusnak,Lisa M. Shewchuk,James Marvin Veal,Duncan Herrick Walker,Lee F. Kuyper +20 more
TL;DR: Two closely related classes of oxindole-based compounds were shown to potently inhibit cyclin-dependent kinase 2 (CDK2) and showed potential utility in the prevention of chemotherapy-induced alopecia.
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NMR solution structure of a peptide nucleic acid complexed with RNA.
TL;DR: The achiral PNA backbone assumed a distinct conformation upon binding that differed from previously proposed models and provides a basis for further structure-based design of antisense agents.
Journal ArticleDOI
The discovery of potent cRaf1 kinase inhibitors
Karen Lackey,Michael Cory,Ronda Davis,Stephen V. Frye,Philip A. Harris,Robert N. Hunter,David Kendall Jung,O. Bradley McDonald,Robert W. McNutt,Michael Robert Peel,Randy D. Rutkowske,James Marvin Veal,Edgar R. Wood +12 more
TL;DR: A series of benzylidene-1H-indol-2-one (oxindole) derivatives was synthesized and evaluated as cRaf-1 kinase inhibitors and inhibited the intracellular MAPK pathway.