J
James N. Ihle
Researcher at St. Jude Children's Research Hospital
Publications - 284
Citations - 49163
James N. Ihle is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Signal transduction & Interleukin 3. The author has an hindex of 110, co-authored 284 publications receiving 48182 citations. Previous affiliations of James N. Ihle include Columbia University & Ben-Gurion University of the Negev.
Papers
More filters
Journal ArticleDOI
STATs: signal transducers and activators of transcription.
TL;DR: Regarding biological functions, it can be anticipated that in the very near future the phenotypes of mice deficient in the remaining STATs will be described and will thus eliminate further speculation, and it would seem less likely as time goes on that additional family members will emerge.
Journal ArticleDOI
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.
Kazuya Shimoda,Jan van Deursent,Mark Y. Sangster,S R Sarawar,Richard T. Carson,Ralph A. Tripp,Charles C. Chu,Frederick W. Quelle,Tetsuya Nosaka,Dario A. A. Vignali,Peter C. Doherty,Gerard Grosveld,William E. Paul,James N. Ihle +13 more
TL;DR: Stat6-l- mice were deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, and immunoglobulin class switching to IgE, indicating the lack of a non-redundant function in normal development.
Journal ArticleDOI
Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses
Stephan Teglund,Catriona McKay,Erin G. Schuetz,Jan M. van Deursen,Dimitrios J. Stravopodis,Demin Wang,Michael Brown,Sara Bodner,Gerard Grosveld,James N. Ihle,James N. Ihle +10 more
TL;DR: The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin.
Journal ArticleDOI
Cytokine receptor signalling
TL;DR: Many cell functions are regulated by members of the cytokine receptor superfamily, a family of transcription factors that contribute to the diversity of cytokine responses.
Journal ArticleDOI
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
William E. Thierfelder,J. M. Van Deursen,K. Yamamoto,Ralph A. Tripp,S. R. Sarawar,R. T. Carson,Mark Y. Sangster,Dario A. A. Vignali,Peter C. Doherty,G. C. Grosveld,James N. Ihle +10 more
TL;DR: All IL-12 functions tested were disrupted, including the induction of IFN-γ, mitogenesis, enhancement of natural killer cytolytic function and Thl differentiation.