J
James R. Bain
Researcher at Duke University
Publications - 150
Citations - 18149
James R. Bain is an academic researcher from Duke University. The author has contributed to research in topics: Insulin resistance & Internal medicine. The author has an hindex of 44, co-authored 133 publications receiving 15318 citations. Previous affiliations of James R. Bain include W. L. Gore and Associates & University of Vermont.
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Journal ArticleDOI
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Vanessa K. Ridaura,Jeremiah J. Faith,Federico E. Rey,Jiye Cheng,Alexis E. Duncan,Andrew L. Kau,Nicholas W. Griffin,Vincent Lombard,Bernard Henrissat,Bernard Henrissat,James R. Bain,Michael J. Muehlbauer,Olga Ilkayeva,Clay F. Semenkovich,Katsuhiko Funai,David K. Hayashi,Barbara J. Lyle,Margaret C. Martini,Luke K. Ursell,Jose C. Clemente,Will Van Treuren,William A. Walters,Rob Knight,Rob Knight,Christopher B. Newgard,Andrew C. Heath,Jeffrey I. Gordon +26 more
TL;DR: The results reveal that transmissible and modifiable interactions between diet and microbiota influence host biology and that adiposity is transmissible from human to mouse and that it was associated with changes in serum levels of branched-chain amino acids.
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A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
Christopher B. Newgard,Jie An,James R. Bain,Michael J. Muehlbauer,Robert Stevens,Lillian F. Lien,Andrea M. Haqq,Svati H. Shah,Michelle Arlotto,Cris A. Slentz,James Rochon,Dianne Gallup,Olga Ilkayeva,Brett R. Wenner,William S. Yancy,Howard Eisenson,Gerald Musante,Richard S. Surwit,David S. Millington,Mark D. Butler,Laura P. Svetkey +20 more
TL;DR: Findings show that in the context of a dietary pattern that includes high fat consumption, BCAA contributes to development of obesity-associated insulin resistance.
Journal ArticleDOI
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
Timothy R. Koves,John R. Ussher,Robert C. Noland,Dorothy H. Slentz,Merrie Mosedale,Olga Ilkayeva,James R. Bain,Robert Stevens,Jason R.B. Dyck,Christopher B. Newgard,Gary D. Lopaschuk,Deborah M. Muoio +11 more
TL;DR: Target metabolomics finds that obesity-related insulin resistance in skeletal muscle is characterized by excessive beta-oxidation, impaired switching to carbohydrate substrate during the fasted-to-fed transition, and coincident depletion of organic acid intermediates of the tricarboxylic acid cycle.
Journal ArticleDOI
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Matthew D. Hirschey,Tadahiro Shimazu,Tadahiro Shimazu,Eric S. Goetzman,Enxuan Jing,Bjoern Schwer,Bjoern Schwer,Bjoern Schwer,David B. Lombard,Carrie A. Grueter,Charles A. Harris,Sudha B. Biddinger,Olga Ilkayeva,Robert Stevens,Yu Li,Asish K. Saha,Neil B. Ruderman,James R. Bain,Christopher B. Newgard,Robert V. Farese,Frederick W. Alt,C. Ronald Kahn,Eric Verdin,Eric Verdin +23 more
TL;DR: It is demonstrated that SIRT3 modulates mitochondrial intermediary metabolism and fatty-acid use during fasting and acetylation is identified as a novel regulatory mechanism for mitochondrial fatty- acid oxidation.
Journal ArticleDOI
The Impact of a Consortium of Fermented Milk Strains on the Gut Microbiome of Gnotobiotic Mice and Monozygotic Twins
Nathan P. McNulty,Tanya Yatsunenko,Ansel Hsiao,Jeremiah J. Faith,Brian D. Muegge,Andrew L. Goodman,Bernard Henrissat,Raish Oozeer,Stéphanie Cools-Portier,Guillaume Gobert,Christian Chervaux,Dan Knights,Catherine A. Lozupone,Rob Knight,Alexis E. Duncan,James R. Bain,Michael J. Muehlbauer,Christopher B. Newgard,Andrew C. Heath,Jeffrey I. Gordon +19 more
TL;DR: The findings show that mice containing a sequenced model human gut microbiome can serve as part of a preclinical discovery pipeline designed to identify the effects of existing or new bacterial species with purported health benefits on the gut microbiomes of various human populations.