James Spencer

TL;DR: The emergence of MCR-1 heralds the breach of the last group of antibiotics, polymyxins, by plasmid-mediated resistance, in Enterobacteriaceae and emphasise the urgent need for coordinated global action in the fight against pan-drug-resistant Gram-negative bacteria.

TL;DR: It is contended that issues including continuing unresolved questions around mechanism; opportunities afforded by new technologies such as serial femtosecond crystallography; the need for new inhibitors, particularly for MBLs; the likely impact of new β-lactam:inhibitor combinations and the continuing clinical importance of β- lactams mean that this remains a rewarding research area.

TL;DR: Relaxation rates for folding and unfolding of two proteins have been measured over a range of denaturant concentrations to examine the reaction pathways leading to the late transition state and results reveal the existence of a single intermediate.

TL;DR: This article showed that cyclic boronates potently inhibit both nucleophilic serine and zinc-dependent β-lactamases by a mechanism involving mimicking of the common tetrahedral intermediate.

TL;DR: The involvement of α4β2* nAChR in the presynaptic modulation of striatal dopamine release is supported and the utility of exploiting a novel partial agonist, together with a selective antagonist, to dissect the functional roles of nA ChR subtypes in the brain is illustrated.