J
James T. Morton
Researcher at University of California, San Diego
Publications - 69
Citations - 9177
James T. Morton is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Microbiome & Metagenomics. The author has an hindex of 27, co-authored 61 publications receiving 5743 citations. Previous affiliations of James T. Morton include Miami University & University of California, Berkeley.
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Journal ArticleDOI
A communal catalogue reveals Earth’s multiscale microbial diversity
Luke R. Thompson,Luke R. Thompson,Luke R. Thompson,Jon G. Sanders,Daniel McDonald,Amnon Amir,Joshua Ladau,Kenneth J. Locey,Robert J. Prill,Anupriya Tripathi,Sean M. Gibbons,Sean M. Gibbons,Gail Ackermann,Jose A. Navas-Molina,Stefan Janssen,Evguenia Kopylova,Yoshiki Vázquez-Baeza,Antonio Gonzalez,James T. Morton,Siavash Mirarab,Zhenjiang Zech Xu,Lingjing Jiang,Mohamed F. Haroon,Jad N. Kanbar,Qiyun Zhu,Se Jin Song,Tomasz Kosciolek,Nicholas A. Bokulich,Joshua P Lefler,Colin J. Brislawn,Gregory Humphrey,Sarah M. Owens,Jarrad T. Hampton-Marcell,Jarrad T. Hampton-Marcell,Donna Berg-Lyons,Valerie J. McKenzie,Noah Fierer,Noah Fierer,Jed A. Fuhrman,Aaron Clauset,Rick Stevens,Rick Stevens,Ashley Shade,Katherine S. Pollard,Kelly D. Goodwin,Janet K. Jansson,Jack A. Gilbert,Jack A. Gilbert,Rob Knight +48 more
TL;DR: A meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project is presented, creating both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity.
Journal ArticleDOI
Deblur Rapidly Resolves Single-Nucleotide Community Sequence Patterns
Amnon Amir,Daniel McDonald,Jose A. Navas-Molina,Evguenia Kopylova,James T. Morton,Zhenjiang Zech Xu,Eric P. Kightley,Luke R. Thompson,Embriette R. Hyde,Antonio Gonzalez,Rob Knight +10 more
TL;DR: A novel sub-operational-taxonomic-unit (sOTU) approach that uses error profiles to obtain putative error-free sequences from Illumina MiSeq and HiSeq sequencing platforms, Deblur, which substantially reduces computational demands relative to similar sOTU methods and does so with similar or better sensitivity and specificity.
Journal ArticleDOI
Best practices for analysing microbiomes.
Rob Knight,Alison Vrbanac,Bryn C. Taylor,Alexander A. Aksenov,Chris Callewaert,Chris Callewaert,Justine W. Debelius,Antonio Gonzalez,Tomasz Kosciolek,Laura-Isobel McCall,Daniel McDonald,Alexey V. Melnik,James T. Morton,Jose Navas,Robert A. Quinn,Jon G. Sanders,Austin D. Swafford,Luke R. Thompson,Luke R. Thompson,Anupriya Tripathi,Zhenjiang Zech Xu,Jesse R. Zaneveld,Qiyun Zhu,J. Gregory Caporaso,Pieter C. Dorrestein,Pieter C. Dorrestein +25 more
TL;DR: This Review focuses on recent findings that suggest that operational taxonomic unit-based analyses should be replaced with new methods that are based on exact sequence variants, methods for integrating metagenomic and metabolomic data, and issues surrounding compositional data analysis.
Journal ArticleDOI
Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome
Erin M. Hill-Burns,Justine W. Debelius,James T. Morton,William T. Wissemann,Matthew R. Lewis,Zachary D. Wallen,Shyamal D. Peddada,Stewart A. Factor,Eric Molho,Cyrus P. Zabetian,Rob Knight,Haydeh Payami +11 more
TL;DR: There is mounting evidence for a connection between the gut and Parkinson's disease (PD).
Journal ArticleDOI
Microbiome-wide association studies link dynamic microbial consortia to disease
Jack A. Gilbert,Robert A. Quinn,Justine W. Debelius,Zhenjiang Zech Xu,James T. Morton,Neha Garg,Neha Garg,Janet K. Jansson,Pieter C. Dorrestein,Rob Knight +9 more
TL;DR: An appreciation of the complexity of interactions among the microbiome and the host's diet, chemistry and health, as well as determining the frequency of observations that are needed to capture and integrate this dynamic interface, is paramount for developing precision diagnostics and therapies based on the microbiome.