J
Jan Albert Kuivenhoven
Researcher at University Medical Center Groningen
Publications - 182
Citations - 16771
Jan Albert Kuivenhoven is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 56, co-authored 168 publications receiving 14855 citations. Previous affiliations of Jan Albert Kuivenhoven include University Medical Center & University of Groningen.
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Journal ArticleDOI
Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society
Børge G. Nordestgaard,M. John Chapman,Steve E. Humphries,Henry N. Ginsberg,Luis Masana,Olivier S. Descamps,Olov Wiklund,Robert A. Hegele,Frederick J. Raal,Joep C. Defesche,Albert Wiegman,Raul D. Santos,Gerald F. Watts,Klaus G. Parhofer,G. Kees Hovingh,Petri T. Kovanen,Catherine Boileau,Maurizio Averna,Jan Borén,Eric Bruckert,Alberico L. Catapano,Jan Albert Kuivenhoven,Jan Albert Kuivenhoven,P. Pajukanta,Kausik K. Ray,Anton F. H. Stalenhoef,Erik S.G. Stroes,Marja-Riitta Taskinen,Anne Tybjærg-Hansen +28 more
TL;DR: There is an urgent worldwide need for diagnostic screening together with early and aggressive treatment of this extremely high-risk condition, familial hypercholesterolaemia.
Journal ArticleDOI
Lipoprotein(a) as a cardiovascular risk factor: current status
Børge G. Nordestgaard,M. John Chapman,Kausik K. Ray,Jan Borén,Felicita Andreotti,Gerald F. Watts,Henry N. Ginsberg,Pierre Amarenco,Alberico L. Catapano,Olivier S. Descamps,Edward A. Fisher,Petri T. Kovanen,Jan Albert Kuivenhoven,Philippe Lesnik,Luis Masana,Zeljko Reiner,Marja-Riitta Taskinen,Lale Tokgozoglu,Anne Tybjærg-Hansen +18 more
TL;DR: The robust and specific association between elevated Lp(a) levels and increased cardiovascular disease (CVD)/coronary heart disease (CHD) risk, together with recent genetic findings, indicates that elevated LP(a), like elevated LDL-cholesterol, is causally related to premature CVD/CHD.
Journal ArticleDOI
Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
M. John Chapman,Henry N. Ginsberg,Pierre Amarenco,Felicita Andreotti,Jan Borén,Alberico L. Catapano,Olivier S. Descamps,Edward A. Fisher,Petri T. Kovanen,Jan Albert Kuivenhoven,Philippe Lesnik,Luis Masana,Børge G. Nordestgaard,Kausik K. Ray,Zeljko Reiner,Marja-Riitta Taskinen,Lale Tokgozoglu,Anne Tybjærg-Hansen,Gerald F. Watts +18 more
TL;DR: Recommendations will facilitate reduction in the substantial cardiovascular risk that persists in patients with cardiometabolic abnormalities at LDL-C goal, and that therapeutic targeting of elevated triglycerides, a marker of TRL and their remnants, and/or low HDL-C may provide further benefit.
Journal ArticleDOI
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society
Marina Cuchel,Eric Bruckert,Henry N. Ginsberg,Frederick J. Raal,Raul D. Santos,Robert A. Hegele,Jan Albert Kuivenhoven,Børge G. Nordestgaard,Olivier S. Descamps,Elisabeth Steinhagen-Thiessen,Anne Tybjærg-Hansen,Gerald F. Watts,Maurizio Averna,Catherine Boileau,Jan Borén,A.L. Catapano,Joep C. Defesche,G. Kees Hovingh,Steve E. Humphries,Petri T. Kovanen,Luis Masana,Päivi Pajukanta,Klaus G. Parhofer,Kausik K. Ray,Anton F. H. Stalenhoef,Erik S.G. Stroes,Marja-Riitta Taskinen,Albert Wiegman,Olov Wiklund,M. John Chapman +29 more
TL;DR: In this article, the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society (EAS) critically reviewed available data with the aim of providing clinical guidance for the recognition and management of HoFH.
Journal ArticleDOI
Effect of Torcetrapib on Carotid Atherosclerosis in Familial Hypercholesterolemia
John J.P. Kastelein,Sander I. van Leuven,Leslie Burgess,Greg Evans,Jan Albert Kuivenhoven,Philip J. Barter,James H. Revkin,Diederick E. Grobbee,Ward A. Riley,Charles L. Shear,William T. Duggan,Michiel L. Bots +11 more
TL;DR: In patients with familial hypercholesterolemia, the use of torcetrapib withAtorva statin, as compared with atorvastatin alone, did not result in further reduction of progression of atherosclerosis, as assessed by a combined measure of carotid arterial-wall thickness, and was associated with progression of disease in the common carotids segment.