Author
Jan Bergman
Other affiliations: Södertörn University
Bio: Jan Bergman is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Trimethylsilyl cyanide & Total synthesis. The author has an hindex of 4, co-authored 8 publications receiving 178 citations. Previous affiliations of Jan Bergman include Södertörn University.
Papers
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TL;DR: An account of the authors work on the synthesis of carbazole alkaloids is presented in this article, along with relevant work from other groups as well as a review of hyellazoles and carbazomycins.
Abstract: An account of the authors work on the synthesis of carbazole alkaloids is presented. The treatise also includes relevant work from other groups as well as a review on the synthesis of hyellazoles and carbazomycins. Carbazole alkaloids have received considerable attention, and various aspects of this class have been reviewed by us1 and others.2-10 A rough division of the carbazole alkaloids into three groups can be made. By far the largest group comprises alkaloids isolated from the Rutaceae-family (=the Citrus family). Selected structures are given in Figure 1. The second group contains alkaloids of the hyellazole / carbazomycin type (Figure 2), and in the third group we have placed the alkaloids that will not fall into the above categories (Figure 3). This treatise will be devoted to the synthesis of carbazoles related to the hyellazoles and carbazomycins, with the main emphasis projected to work from our laboratories. A brief discussion of relcvant work concerning the synthesis of the other alkaloids will however also bc included.
107 citations
TL;DR: The indole alkaloid barettin (with bromine in 6 position) isolated from the marine sponge Geodia Barretti, has been synthesised via a Horner-Wadsworth-Emmons type reaction from 6-bromoindole-3-car as discussed by the authors.
41 citations
TL;DR: In this paper, the total synthesis of all four known rhopaladins, A-D, isolated from the Okinawan marine tunicate Rhopalaea sp., in two synthetic steps was described, involving an imidate based cyclization with tryptophan esters as the key step to afford the appropriately substituted imidazolinone unit.
24 citations
TL;DR: The diketopiperazine derivative dipodazine has been synthesized via a stereoselective aldol condensation from N-protected indole-3-carboxaldehyde and 1,4-diacetyl-2,5-piperazinedione in the presence of cesium carbonate.
Abstract: The diketopiperazine derivative dipodazine (1), isolated from Penicillium dipodomyis, has been synthesized via a stereoselective aldol condensation from N-protected indole-3-carboxaldehyde and 1,4-diacetyl-2,5-piperazinedione (3) in the presence of cesium carbonate.
13 citations
TL;DR: The first carbazole alkaloid to be isolated was murrayanine (l), extracted from the stem bark of the small tree Murrayu koenigii in India, and since then, the field has expanded enormously, largely due to the promising biological activities of many of these alkaloids.
3 citations
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TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
4,649 citations
1,143 citations
947 citations
645 citations
TL;DR: This review covers the literature on simple indole alkaloid and those with a nonrearranged monoterpenoid unit and newly isolated alkaloids, structure determinations, total syntheses and biological activities.
531 citations