J
Jan Lötvall
Researcher at University of Gothenburg
Publications - 364
Citations - 52146
Jan Lötvall is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Asthma & Microvesicles. The author has an hindex of 84, co-authored 357 publications receiving 41705 citations. Previous affiliations of Jan Lötvall include University of Tartu & McMaster University.
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Journal ArticleDOI
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
Journal ArticleDOI
Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
Clotilde Théry,Kenneth W. Witwer,Elena Aikawa,María José Alcaraz,Johnathon D. Anderson,Ramaroson Andriantsitohaina,Anna Antoniou,Anna Antoniou,Tanina Arab,Fabienne Archer,Georgia K. Atkin-Smith,D. Craig Ayre,Jean Marie Bach,Daniel Bachurski,Hossein Baharvand,Hossein Baharvand,Leonora Balaj,Shawn Baldacchino,Natalie N. Bauer,Amy A. Baxter,Mary Bebawy,Carla Beckham,Apolonija Bedina Zavec,Abderrahim Benmoussa,Anna Berardi,Paolo Bergese,Ewa Bielska,Cherie Blenkiron,Sylwia Bobis-Wozowicz,Eric Boilard,Wilfrid Boireau,Antonella Bongiovanni,Francesc E. Borràs,Steffi Bosch,Chantal M. Boulanger,Chantal M. Boulanger,Xandra O. Breakefield,Andrew M. Breglio,Andrew M. Breglio,Meadhbh Á. Brennan,Meadhbh Á. Brennan,David R. Brigstock,David R. Brigstock,Alain Brisson,Marike L. D. Broekman,Marike L. D. Broekman,Jacqueline Bromberg,Paulina Bryl-Górecka,Shilpa Buch,Amy H. Buck,Dylan Burger,Sara Busatto,Sara Busatto,Dominik Buschmann,Benedetta Bussolati,Edit I. Buzás,Edit I. Buzás,James Bryan Byrd,Giovanni Camussi,David R. F. Carter,Sarah Caruso,Lawrence W. Chamley,Yu Ting Chang,Amrita Datta Chaudhuri,Chihchen Chen,Shuai Chen,Lesley Cheng,Andrew Chin,Aled Clayton,Stefano P. Clerici,Alex Cocks,Emanuele Cocucci,Robert J. Coffey,Anabela Cordeiro-da-Silva,Yvonne Couch,Frank A. W. Coumans,Beth Coyle,Rossella Crescitelli,Miria Ferreira Criado,Crislyn D'Souza-Schorey,Saumya Das,Paola de Candia,Eliezer F. De Santana,Olivier De Wever,Hernando A. del Portillo,Tanguy Demaret,Sarah Deville,Sarah Deville,Andrew Devitt,Bert Dhondt,Dolores Di Vizio,Lothar C. Dieterich,Vincenza Dolo,Ana Paula Domínguez Rubio,Massimo Dominici,Mauricio Rocha Dourado,Mauricio Rocha Dourado,Tom A. P. Driedonks,Filipe V. Duarte,Heather M. Duncan,Ramon M. Eichenberger,Karin M. Ekström,Samir El Andaloussi,Celine Elie-Caille,Uta Erdbrügger,Juan M. Falcón-Pérez,Farah Fatima,Jason E. Fish,Jason E. Fish,Miguel Flores-Bellver,András Försönits,Annie Frelet-Barrand,Fabia Fricke,Fabia Fricke,Gregor Fuhrmann,Susanne Gabrielsson,Ana Gámez-Valero,Chris Gardiner,Kathrin Gärtner,Raphael Gaudin,Raphael Gaudin,Yong Song Gho,Bernd Giebel,Caroline Gilbert,Mario Gimona,Ilaria Giusti,Deborah C.I. Goberdhan,André Görgens,André Görgens,Sharon M. Gorski,David W. Greening,Julia Christina Gross,Alice Gualerzi,Gopal N. Gupta,Dakota Gustafson,Aase Handberg,Reka A. Haraszti,Paul Harrison,Hargita Hegyesi,An Hendrix,Andrew F. Hill,Fred H. Hochberg,Karl F. Hoffmann,Beth Holder,Harry Holthöfer,Baharak Hosseinkhani,Guoku Hu,Yiyao Huang,Yiyao Huang,Veronica Huber,Stuart Hunt,Ahmed Ibrahim,Tsuneya Ikezu,Jameel M. Inal,Mustafa Isin,Alena Ivanova,Hannah K Jackson,Søren Jacobsen,Steven M. Jay,Muthuvel Jayachandran,Guido Jenster,Lanzhou Jiang,Suzanne M. Johnson,Jennifer Jones,Ambrose Jong,Tijana Jovanovic-Talisman,Stephanie M. Jung,Raghu Kalluri,Shin Ichi Kano,Sukhbir Kaur,Yumi Kawamura,Yumi Kawamura,Evan T. Keller,Delaram Khamari,Elena Khomyakova,Anastasia Khvorova,Peter Kierulf,Kwang Pyo Kim,Thomas Kislinger,Thomas Kislinger,Mikael Klingeborn,David J. Klinke,Miroslaw Kornek,Maja Kosanović,Árpád Kovács,Eva-Maria Krämer-Albers,Susanne Krasemann,Mirja Krause,Igor V. Kurochkin,Gina D. Kusuma,Gina D. Kusuma,Sören Kuypers,Saara Laitinen,Scott M. Langevin,Lucia R. Languino,Joanne Lannigan,Cecilia Lässer,Louise C. Laurent,Grégory Lavieu,Elisa Lázaro-Ibáñez,Soazig Le Lay,Myung-Shin Lee,Yi Xin Fiona Lee,Débora S. Lemos,Metka Lenassi,Aleksandra Leszczynska,Isaac T. S. Li,Ke Liao,Sten F.W.M. Libregts,Erzsébet Ligeti,Rebecca Lim,Rebecca Lim,Sai Kiang Lim,Aija Linē,Karen Linnemannstöns,Alicia Llorente,Catherine Lombard,Magdalena J. Lorenowicz,Ákos M. Lörincz,Jan Lötvall,Jason Lovett,Michelle C. Lowry,Xavier Loyer,Xavier Loyer,Quan Lu,Barbara Lukomska,Taral R. Lunavat,Sybren L. N. Maas,Harmeet Malhi,Antonio Marcilla,Jacopo Mariani,Javier Mariscal,Elena S. Martens-Uzunova,Lorena Martin-Jaular,M. Carmen Martinez,Vilma R. Martins,Mathilde Mathieu,Suresh Mathivanan,Marco Maugeri,Lynda K. McGinnis,Mark J. McVey,David G. Meckes,Katie Meehan,Inge Mertens,Inge Mertens,Valentina R. Minciacchi,Andreas Möller,Malene Jørgensen,Aizea Morales-Kastresana,Jess Morhayim,François Mullier,Maurizio Muraca,Luca Musante,Veronika Mussack,Dillon C. Muth,Kathryn H. Myburgh,Tanbir Najrana,Muhammad Nawaz,Irina Nazarenko,Irina Nazarenko,Peter Nejsum,Christian Neri,Tommaso Neri,Rienk Nieuwland,Leonardo Nimrichter,John P. Nolan,Esther N. M. Nolte-‘t Hoen,Nicole Noren Hooten,Lorraine O'Driscoll,Tina O'Grady,Ana O'Loghlen,Takahiro Ochiya,Martin Olivier,Alberto Ortiz,Luis A. Ortiz,Xabier Osteikoetxea,Ole Ostegaard,Ole Ostegaard,Matias Ostrowski,Jaesung Park,D. Michiel Pegtel,Héctor Peinado,Francesca Perut,Michael W. Pfaffl,Donald G. Phinney,Bartijn C. H. Pieters,Ryan C. Pink,David S. Pisetsky,Elke Pogge von Strandmann,Iva Polakovicova,Ivan K. H. Poon,Bonita H. Powell,Ilaria Prada,Lynn Pulliam,Lynn Pulliam,Peter J. Quesenberry,Annalisa Radeghieri,Robert L. Raffai,Robert L. Raffai,Stefania Raimondo,Janusz Rak,Marcel I. Ramirez,Marcel I. Ramirez,Graça Raposo,Morsi S. Rayyan,Neta Regev-Rudzki,Franz Ricklefs,Paul D. Robbins,David D. Roberts,Silvia C Rodrigues,Eva Rohde,Sophie Rome,Kasper M.A. Rouschop,Aurelia Rughetti,Ashley E. Russell,Paula Saa,Susmita Sahoo,Edison Salas-Huenuleo,Catherine Sánchez,Julie A. Saugstad,Meike J. Saul,Raymond M. Schiffelers,Raphael Schneider,Tine Hiorth Schøyen,Aaron Scott,Eriomina Shahaj,Shivani Sharma,Olga Shatnyeva,Faezeh Shekari,Ganesh Vilas Shelke,Ashok K. Shetty,Kiyotaka Shiba,Pia Siljander,Andreia M. Silva,Agata Skowronek,Orman L. Snyder,Rodrigo Pedro Soares,Barbara W Sódar,Carolina Soekmadji,Carolina Soekmadji,Javier Sotillo,Philip D. Stahl,Willem Stoorvogel,Shannon L. Stott,Erwin Strasser,Simon Swift,Hidetoshi Tahara,Muneesh Tewari,Kate Timms,Swasti Tiwari,Swasti Tiwari,Rochelle Tixeira,Mercedes Tkach,Wei Seong Toh,Richard Tomasini,Ana Claudia Torrecilhas,Juan Pablo Tosar,Juan Pablo Tosar,Vasilis Toxavidis,Lorena Urbanelli,Pieter Vader,Bas W.M. van Balkom,Susanne G. van der Grein,Jan Van Deun,Martijn J. C. van Herwijnen,Kendall Van Keuren-Jensen,Guillaume van Niel,Martin E. van Royen,Andre J. van Wijnen,M. Helena Vasconcelos,Ivan J. Vechetti,Tiago Degani Veit,Laura J Vella,Laura J Vella,Emilie Velot,Frederik J. Verweij,Beate Vestad,Jose L. Viñas,Tamás Visnovitz,Krisztina V. Vukman,Jessica Wahlgren,Dionysios C. Watson,Marca H. M. Wauben,Alissa M. Weaver,Jason P. Webber,Viktoria Weber,Ann M. Wehman,Daniel J. Weiss,Joshua A. Welsh,Sebastian Wendt,Åsa M. Wheelock,Zoltán Wiener,Leonie Witte,Joy Wolfram,Joy Wolfram,Joy Wolfram,Angeliki Xagorari,Patricia Xander,Jing Xu,Xiaomei Yan,María Yáñez-Mó,María Yáñez-Mó,Hang Yin,Yuana Yuana,Valentina Zappulli,Jana Zarubova,Jana Zarubova,Vytautas Žėkas,Jian ye Zhang,Zezhou Zhao,Lei Zheng,Alexander R. Zheutlin,Antje M. Zickler,Pascale Zimmermann,Pascale Zimmermann,Angela M. Zivkovic,Davide Zocco,Ewa K. Zuba-Surma +417 more
TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.
Journal ArticleDOI
Biological properties of extracellular vesicles and their physiological functions
María Yáñez-Mó,Pia Siljander,Zoraida Andreu,Apolonija Bedina Zavec,Francesc E. Borràs,Edit I. Buzás,Krisztina Buzas,Krisztina Buzas,Enriqueta Casal,Francesco Cappello,Joana Carvalho,Joana Carvalho,Eva Colas,Anabela Cordeiro da Silva,Anabela Cordeiro da Silva,Stefano Fais,Juan M. Falcón-Pérez,Irene M. Ghobrial,Bernd Giebel,Mario Gimona,Mario Gimona,Michael W. Graner,Ihsan Gursel,Mayda Gursel,Niels H. H. Heegaard,Niels H. H. Heegaard,An Hendrix,Peter Kierulf,Katsutoshi Kokubun,Maja Kosanović,Veronika Kralj-Iglič,Eva-Maria Krämer-Albers,Saara Laitinen,Cecilia Lässer,Thomas Lener,Thomas Lener,Erzsébet Ligeti,Aija Linē,Georg Lipps,Alicia Llorente,Jan Lötvall,Mateja Manček-Keber,Antonio Marcilla,María Mittelbrunn,Irina Nazarenko,Esther N. M. Nolte-‘t Hoen,Tuula A. Nyman,Lorraine O'Driscoll,Mireia Olivan,Carla Oliveira,Carla Oliveira,Éva Pállinger,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Reventós,Jaume Reventós,Marina Rigau,Eva Rohde,Eva Rohde,Marei Sammar,Francisco Sánchez-Madrid,Nuno Santarém,Nuno Santarém,Katharina Schallmoser,Katharina Schallmoser,Marie Stampe Ostenfeld,Willem Stoorvogel,Roman Štukelj,Susanne G. van der Grein,M. Helena Vasconcelos,M. Helena Vasconcelos,Marca H. M. Wauben,Olivier De Wever +72 more
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
Journal ArticleDOI
Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles.
Jan Lötvall,Andrew F. Hill,Fred H. Hochberg,Edit I. Buzás,Dolores Di Vizio,Chris Gardiner,Yong Song Gho,Igor V. Kurochkin,Suresh Mathivanan,Peter J. Quesenberry,Susmita Sahoo,Hidetoshi Tahara,Marca H. M. Wauben,Kenneth W. Witwer,Clotilde Théry +14 more
TL;DR: The International Society for Extracellular Vesicles (ISEV) provides researchers with a minimal set of biochemical, biophysical and functional standards that should be used to attribute any specific biological cargo or functions to EVs.
Journal ArticleDOI
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
Kenneth W. Witwer,Edit I. Buzás,Lynne T. Bemis,Adriana Bora,Cecilia Lässer,Jan Lötvall,Esther Nolte-‘t Hoen,Melissa G. Piper,Sarada Sivaraman,Johan Skog,Clotilde Théry,Marca H. M. Wauben,Fred H. Hochberg +12 more
TL;DR: The need for standardization of specimen handling, appropriate normative controls, and isolation and analysis techniques to facilitate comparison of results is emphasized, and it is recognized that continual development and evaluation of techniques will be necessary as new knowledge is amassed.