J
Jan Mulder
Researcher at Karolinska Institutet
Publications - 115
Citations - 22177
Jan Mulder is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Gene & Cholinergic. The author has an hindex of 40, co-authored 105 publications receiving 15395 citations. Previous affiliations of Jan Mulder include University of Groningen & Royal Institute of Technology.
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Journal ArticleDOI
Tissue-based map of the human proteome
Mathias Uhlén,Mathias Uhlén,Linn Fagerberg,Björn M. Hallström,Cecilia Lindskog,Per Oksvold,Adil Mardinoglu,Åsa Sivertsson,Caroline Kampf,Evelina Sjöstedt,Evelina Sjöstedt,Anna Asplund,IngMarie Olsson,Karolina Edlund,Emma Lundberg,Sanjay Navani,Cristina Al-Khalili Szigyarto,Jacob Odeberg,Dijana Djureinovic,Jenny Ottosson Takanen,Sophia Hober,Tove Alm,Per-Henrik Edqvist,Holger Berling,Hanna Tegel,Jan Mulder,Johan Rockberg,Peter Nilsson,Jochen M. Schwenk,Marica Hamsten,Kalle von Feilitzen,Mattias Forsberg,Lukas Persson,Fredric Johansson,Martin Zwahlen,Gunnar von Heijne,Jens Nielsen,Jens Nielsen,Fredrik Pontén +38 more
TL;DR: In this paper, a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level.
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Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics
Linn Fagerberg,Björn M. Hallström,Per Oksvold,Caroline Kampf,Dijana Djureinovic,Jacob Odeberg,Masato Habuka,Simin Tahmasebpoor,Angelika Danielsson,Karolina Edlund,Anna Asplund,Evelina Sjöstedt,Emma Lundberg,Cristina Al-Khalili Szigyarto,Marie Skogs,Jenny Ottosson Takanen,Holger Berling,Hanna Tegel,Jan Mulder,Peter Nilsson,Jochen M. Schwenk,Cecilia Lindskog,Frida Danielsson,Adil Mardinoglu,Åsa Sivertsson,Kalle von Feilitzen,Mattias Forsberg,Martin Zwahlen,IngMarie Olsson,Sanjay Navani,Mikael Huss,Jens Nielsen,Jens Nielsen,Fredrik Pontén,Mathias Uhlén +34 more
TL;DR: A quantitative transcriptomics analysis (RNA-Seq) is used to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues.
Journal ArticleDOI
A subcellular map of the human proteome
Peter Thul,Lovisa Åkesson,Mikaela Wiking,Diana Mahdessian,Aikaterini Geladaki,Hammou Ait Blal,Tove Alm,Anna Asplund,Lars Björk,Lisa M. Breckels,Anna Bäckström,Frida Danielsson,Linn Fagerberg,Jenny Fall,Laurent Gatto,Christian Gnann,Sophia Hober,Martin Hjelmare,Fredric Johansson,Sunjae Lee,Cecilia Lindskog,Jan Mulder,Claire M. Mulvey,Peter Nilsson,Per Oksvold,Johan Rockberg,Rutger Schutten,Jochen M. Schwenk,Åsa Sivertsson,Evelina Sjöstedt,Marie Skogs,Charlotte Stadler,Devin P. Sullivan,Hanna Tegel,Casper F. Winsnes,Cheng Zhang,Martin Zwahlen,Adil Mardinoglu,Fredrik Pontén,Kalle von Feilitzen,Kathryn S. Lilley,Mathias Uhlén,Emma Lundberg +42 more
TL;DR: A subcellular map of the human proteome is presented to facilitate functional exploration of individual proteins and their role in human biology and disease and integrated into existing network models of protein-protein interactions for increased accuracy.
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Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
Patrik L. Ståhl,Patrik L. Ståhl,Fredrik Salmén,Sanja Vickovic,Anna Lundmark,Anna Lundmark,José Fernández Navarro,José Fernández Navarro,Jens P. Magnusson,Stefania Giacomello,Michaela Asp,Jakub Orzechowski Westholm,Mikael Huss,Annelie Mollbrink,Sten Linnarsson,Simone Codeluppi,Åke Borg,Fredrik Pontén,Paul I. Costea,Pelin Sahlén,Jan Mulder,Olaf Bergmann,Joakim Lundeberg,Jonas Frisén +23 more
TL;DR: By positioning histological sections on arrayed reverse transcription primers with unique positional barcodes, this work demonstrates high-quality RNA-sequencing data with maintained two-dimensional positional information from the mouse brain and human breast cancer.
Journal ArticleDOI
Hardwiring the brain: endocannabinoids shape neuronal connectivity.
Paul Berghuis,Ann M. Rajnicek,Yury M. Morozov,Ruth A. Ross,Jan Mulder,Gabriella M. Urbán,Krisztina Monory,Giovanni Marsicano,Michela Matteoli,Alison J. Canty,Andrew J. Irving,István Katona,Yuchio Yanagawa,Pasko Rakic,Beat Lutz,Ken Mackie,Tibor Harkany +16 more
TL;DR: This work reports that CB1 cannabinoid receptors are enriched in the axonal growth cones of γ-aminobutyric acid–containing interneurons in the rodent cortex during late gestation and demonstrates that endocannabinoid signaling regulates synaptogenesis and target selection in vivo.