J
Jan Papies
Researcher at Charité
Publications - 11
Citations - 785
Jan Papies is an academic researcher from Charité. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 7, co-authored 9 publications receiving 432 citations. Previous affiliations of Jan Papies include University of Bonn & Humboldt University of Berlin.
Papers
More filters
Journal ArticleDOI
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection
Nils C. Gassen,Daniela Niemeyer,Doreen Muth,Victor M. Corman,Silvia Martinelli,Alwine Gassen,Kathrin Hafner,Jan Papies,Kirstin Mösbauer,Andreas Zellner,Anthony S. Zannas,Alexander M. Herrmann,Florian Holsboer,Ruth Brack-Werner,Michael Boshart,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Christian Drosten,Marcel A. Müller,Theo Rein,Theo Rein +20 more
TL;DR: It is shown that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replication of MERS coronavirus.
Journal ArticleDOI
Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy.
Emanuel Wyler,Kirstin Mösbauer,Vedran Franke,Asija Diag,Lina Theresa Gottula,Roberto Arsie,Filippos Klironomos,Filippos Klironomos,David Koppstein,Katja Hönzke,Salah Ayoub,Christopher Buccitelli,Karen Hoffmann,Anja Richter,Ivano Legnini,Andranik Ivanov,Tommaso Mari,Simone Del Giudice,Jan Papies,Samantha D. Praktiknjo,Thomas F. Meyer,Marcel A. Müller,Daniela Niemeyer,Andreas C. Hocke,Matthias Selbach,Altuna Akalin,Nikolaus Rajewsky,Christian Drosten,Markus Landthaler,Markus Landthaler +29 more
TL;DR: In this article, gene expression profiles of three SARS-CoV and SARS CoV-2 infected human cell lines were reported, and it was shown that SARS co-virus infection elicited an approximately two-fold higher stimulation of the innate immune response compared to SARS in the human epithelial cell line Calu-3, including induction of miRNA-155.
Journal ArticleDOI
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Jackson Emanuel,Jackson Emanuel,Frederik Dethloff,Robert Lorenz Chua,Jakob Trimpert,Nicolas Heinemann,Nicolas Heinemann,Christine Niemeyer,Friderike Weege,Friderike Weege,Katja Hönzke,Tom Aschman,Daniel E. Heinz,Katja Weckmann,Tim Ebert,Andreas Zellner,M. Lennarz,Emanuel Wyler,Simon Schroeder,Simon Schroeder,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Karen Hoffmann,Thomas F. Meyer,Frank L. Heppner,Frank L. Heppner,Victor M. Corman,Victor M. Corman,Markus Landthaler,Markus Landthaler,Andreas C. Hocke,Markus Morkel,Markus Morkel,Nikolaus Osterrieder,Nikolaus Osterrieder,Christian Conrad,Roland Eils,Roland Eils,Helena Radbruch,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller +48 more
TL;DR: In this paper, the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Posted ContentDOI
Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Frederik Dethloff,Jackson Emanuel,Jackson Emanuel,Katja Weckmann,Daniel E. Heinz,Nicolas Heinemann,Nicolas Heinemann,M. Lennarz,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Victor M. Corman,Victor M. Corman,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller,Marcel A. Müller +22 more
TL;DR: It is shown that SARS-CoV-2 infection limits autophagy by interfering with multiple metabolic pathways and that compound-driven interventions aimed at Autophagy induction reduce Sars-Cov-2 propagation in vitro.
Posted ContentDOI
Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identifies molecular targets for therapeutic intervention
Emanuel Wyler,Kirstin Mösbauer,Vedran Franke,Asija Diag,Lina Theresa Gottula,Roberto Arsie,Filippos Klironomos,David Koppstein,Salah Ayoub,Christopher Buccitelli,Anja Richter,Ivano Legnini,Andranik Ivanov,Tommaso Mari,Simone Del Giudice,Jan Papies,Marcel A. Müller,Daniela Niemeyer,Matthias Selbach,Altuna Akalin,Nikolaus Rajewsky,Christian Drosten,Markus Landthaler +22 more
TL;DR: In vitro cell culture models are established to study SARS-CoV-2 infection and heat shock protein 90 (HSP90) protein is identified as a potential drug target for therapeutic intervention of Sars-CoVs infection.