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Author

Jan Putzeys

Other affiliations: IMEC
Bio: Jan Putzeys is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: CMOS & Electronic circuit. The author has an hindex of 17, co-authored 37 publications receiving 4197 citations. Previous affiliations of Jan Putzeys include IMEC.

Papers
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Journal ArticleDOI
TL;DR: The Photodetector Array Camera and Spectrometer (PACS) as discussed by the authors is one of the three science instruments on ESA's far infrared and sub-mil- limetre observatory.
Abstract: The Photodetector Array Camera and Spectrometer (PACS) is one of the three science instruments on ESA's far infrared and submil- limetre observatory. It employs two Ge:Ga photoconductor arrays (stressed and unstressed) with 16 × 25 pixels, each, and two filled silicon bolometer arrays with 16 × 32 and 32 × 64 pixels, respectively, to perform integral-field spectroscopy and imaging photom- etry in the 60−210 μm wavelength regime. In photometry mode, it simultaneously images two bands, 60−85 μ mo r 85−125 μ ma nd 125−210 μm, over a field of view of ∼1.75 � × 3.5 � , with close to Nyquist beam sampling in each band. In spectroscopy mode, it images afi eld of 47 �� × 47 �� , resolved into 5 × 5 pixels, with an instantaneous spectral coverage of ∼ 1500 km s −1 and a spectral resolution of ∼175 km s −1 . We summarise the design of the instrument, describe observing modes, calibration, and data analysis methods, and present our current assessment of the in-orbit performance of the instrument based on the performance verification tests. PACS is fully operational, and the achieved performance is close to or better than the pre-launch predictions.

2,645 citations

Journal ArticleDOI
08 Nov 2017-Nature
TL;DR: The fully integrated functionality and small size of Neuropixels probes allowed large populations of neurons from several brain structures to be recorded in freely moving animals and opens a path towards recording of brain-wide neural activity during behaviour.
Abstract: New silicon probes known as Neuropixels are shown to record from hundreds of neurons simultaneously in awake and freely moving rodents. Sensory, motor and cognitive operations involve the coordinated action of large neuronal populations across multiple brain regions. Existing technologies reliably measure activity from a relatively small number of neurons with high spatial and temporal resolution, or from a large volume of neurons with low resolution. Timothy Harris and colleagues describe the design, fabrication and performance of Neuropixels, a silicon probe that can measure well-isolated neural activity from hundreds of neurons. They integrated these probes into a lightweight system that could record activity simultaneously and with high fidelity from hundreds of neurons in awake and freely moving rodents. Sensory, motor and cognitive operations involve the coordinated action of large neuronal populations across multiple brain regions in both superficial and deep structures1,2. Existing extracellular probes record neural activity with excellent spatial and temporal (sub-millisecond) resolution, but from only a few dozen neurons per shank. Optical Ca2+ imaging3,4,5 offers more coverage but lacks the temporal resolution needed to distinguish individual spikes reliably and does not measure local field potentials. Until now, no technology compatible with use in unrestrained animals has combined high spatiotemporal resolution with large volume coverage. Here we design, fabricate and test a new silicon probe known as Neuropixels to meet this need. Each probe has 384 recording channels that can programmably address 960 complementary metal–oxide–semiconductor (CMOS) processing-compatible low-impedance TiN6 sites that tile a single 10-mm long, 70 × 20-μm cross-section shank. The 6 × 9-mm probe base is fabricated with the shank on a single chip. Voltage signals are filtered, amplified, multiplexed and digitized on the base, allowing the direct transmission of noise-free digital data from the probe. The combination of dense recording sites and high channel count yielded well-isolated spiking activity from hundreds of neurons per probe implanted in mice and rats. Using two probes, more than 700 well-isolated single neurons were recorded simultaneously from five brain structures in an awake mouse. The fully integrated functionality and small size of Neuropixels probes allowed large populations of neurons from several brain structures to be recorded in freely moving animals. This combination of high-performance electrode technology and scalable chip fabrication methods opens a path towards recording of brain-wide neural activity during behaviour.

1,443 citations

Journal ArticleDOI
16 Apr 2021-Science
TL;DR: A suite of electrophysiological tools comprising a miniaturized high-density probe, recoverable chronic implant fixtures, and algorithms for automatic post hoc motion correction are demonstrated, enabling an order-of-magnitude increase in the number of sites that can be recorded in small animals, such as mice, and the ability to record from them stably over long time scales.
Abstract: Measuring the dynamics of neural processing across time scales requires following the spiking of thousands of individual neurons over milliseconds and months. To address this need, we introduce the Neuropixels 2.0 probe together with newly designed analysis algorithms. The probe has more than 5000 sites and is miniaturized to facilitate chronic implants in small mammals and recording during unrestrained behavior. High-quality recordings over long time scales were reliably obtained in mice and rats in six laboratories. Improved site density and arrangement combined with newly created data processing methods enable automatic post hoc correction for brain movements, allowing recording from the same neurons for more than 2 months. These probes and algorithms enable stable recordings from thousands of sites during free behavior, even in small animals such as mice.

386 citations

Journal ArticleDOI
TL;DR: A 384-channel configurable neural probe for large-scale in vivo recording of neural signals and results show a total input-referred noise of 6.4%, dual-band recording and a 171.6 Mbps digital interface.
Abstract: In vivo recording of neural action-potential and local-field-potential signals requires the use of high-resolution penetrating probes. Several international initiatives to better understand the brain are driving technology efforts towards maximizing the number of recording sites while minimizing the neural probe dimensions. We designed and fabricated (0.13- $\mu$ m SOI Al CMOS) a 384-channel configurable neural probe for large-scale in vivo recording of neural signals. Up to 966 selectable active electrodes were integrated along an implantable shank (70 $\mu$ m wide, 10 mm long, 20 $\mu$ m thick), achieving a crosstalk of $-\text{64.4}$ dB. The probe base (5 $\times$ 9 mm $^2$ ) implements dual-band recording and a 171.6 Mbps digital interface. Measurement results show a total input-referred noise of 6.4 $\mu$ V $_{\mathrm{rms}}$ and a total power consumption of 49.1 $\mu$ W/channel.

139 citations

Journal ArticleDOI
TL;DR: The Photodetector Array Camera and Spectrometer (PACS) as discussed by the authors is one of the three science instruments on ESA's far infrared and submillimetre observatory.
Abstract: The Photodetector Array Camera and Spectrometer (PACS) is one of the three science instruments on ESA's far infrared and submillimetre observatory. It employs two Ge:Ga photoconductor arrays (stressed and unstressed) with 16x25 pixels, each, and two filled silicon bolometer arrays with 16x32 and 32x64 pixels, respectively, to perform integral-field spectroscopy and imaging photometry in the 60-210\mu\ m wavelength regime. In photometry mode, it simultaneously images two bands, 60-85\mu\ m or 85-125\mu\m and 125-210\mu\ m, over a field of view of ~1.75'x3.5', with close to Nyquist beam sampling in each band. In spectroscopy mode, it images a field of 47"x47", resolved into 5x5 pixels, with an instantaneous spectral coverage of ~1500km/s and a spectral resolution of ~175km/s. We summarise the design of the instrument, describe observing modes, calibration, and data analysis methods, and present our current assessment of the in-orbit performance of the instrument based on the Performance Verification tests. PACS is fully operational, and the achieved performance is close to or better than the pre-launch predictions.

127 citations


Cited by
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Journal ArticleDOI
TL;DR: Herschel was launched on 14 May 2009, and is now an operational ESA space observatory o ering unprecedented observational capabilities in the far-infrared and sub-millimetre spectral range 55 671 m.
Abstract: Herschel was launched on 14 May 2009, and is now an operational ESA space observatory o ering unprecedented observational capabilities in the far-infrared and submillimetre spectral range 55 671 m. Herschel carries a 3.5 metre diameter passively cooled Cassegrain telescope, which is the largest of its kind and utilises a novel silicon carbide technology. The science payload comprises three instruments: two direct detection cameras/medium resolution spectrometers, PACS and SPIRE, and a very high-resolution heterodyne spectrometer, HIFI, whose focal plane units are housed inside a superfluid helium cryostat. Herschel is an observatory facility operated in partnership among ESA, the instrument consortia, and NASA. The mission lifetime is determined by the cryostat hold time. Nominally approximately 20,000 hours will be available for astronomy, 32% is guaranteed time and the remainder is open to the worldwide general astronomical community through a standard competitive proposal procedure.

3,359 citations

Journal ArticleDOI
TL;DR: The Photodetector Array Camera and Spectrometer (PACS) as discussed by the authors is one of the three science instruments on ESA's far infrared and sub-mil- limetre observatory.
Abstract: The Photodetector Array Camera and Spectrometer (PACS) is one of the three science instruments on ESA's far infrared and submil- limetre observatory. It employs two Ge:Ga photoconductor arrays (stressed and unstressed) with 16 × 25 pixels, each, and two filled silicon bolometer arrays with 16 × 32 and 32 × 64 pixels, respectively, to perform integral-field spectroscopy and imaging photom- etry in the 60−210 μm wavelength regime. In photometry mode, it simultaneously images two bands, 60−85 μ mo r 85−125 μ ma nd 125−210 μm, over a field of view of ∼1.75 � × 3.5 � , with close to Nyquist beam sampling in each band. In spectroscopy mode, it images afi eld of 47 �� × 47 �� , resolved into 5 × 5 pixels, with an instantaneous spectral coverage of ∼ 1500 km s −1 and a spectral resolution of ∼175 km s −1 . We summarise the design of the instrument, describe observing modes, calibration, and data analysis methods, and present our current assessment of the in-orbit performance of the instrument based on the performance verification tests. PACS is fully operational, and the achieved performance is close to or better than the pre-launch predictions.

2,645 citations

Journal ArticleDOI
TL;DR: In this paper, the authors review progress over the past decade in observations of large-scale star formation, with a focus on the interface between extragalactic and Galactic studies.
Abstract: We review progress over the past decade in observations of large-scale star formation, with a focus on the interface between extragalactic and Galactic studies. Methods of measuring gas contents and star-formation rates are discussed, and updated prescriptions for calculating star-formation rates are provided. We review relations between star formation and gas on scales ranging from entire galaxies to individual molecular clouds.

2,525 citations

Journal ArticleDOI
Matthew Joseph Griffin, Alain Abergel1, A. Abreu, Peter A. R. Ade2  +186 moreInstitutions (27)
TL;DR: The Spectral and Photometric Imaging REceiver (SPIRE) is the Herschel Space Observatory's sub-millimetre camera and spectrometer as discussed by the authors, which is used for image and spectroscopic data acquisition.
Abstract: The Spectral and Photometric Imaging REceiver (SPIRE), is the Herschel Space Observatory`s submillimetre camera and spectrometer It contains a three-band imaging photometer operating at 250, 350 and 500 mu m, and an imaging Fourier-transform spectrometer (FTS) which covers simultaneously its whole operating range of 194-671 mu m (447-1550 GHz) The SPIRE detectors are arrays of feedhorn-coupled bolometers cooled to 03 K The photometer has a field of view of 4' x 8', observed simultaneously in the three spectral bands Its main operating mode is scan-mapping, whereby the field of view is scanned across the sky to achieve full spatial sampling and to cover large areas if desired The spectrometer has an approximately circular field of view with a diameter of 26' The spectral resolution can be adjusted between 12 and 25 GHz by changing the stroke length of the FTS scan mirror Its main operating mode involves a fixed telescope pointing with multiple scans of the FTS mirror to acquire spectral data For extended source measurements, multiple position offsets are implemented by means of an internal beam steering mirror to achieve the desired spatial sampling and by rastering of the telescope pointing to map areas larger than the field of view The SPIRE instrument consists of a cold focal plane unit located inside the Herschel cryostat and warm electronics units, located on the spacecraft Service Module, for instrument control and data handling Science data are transmitted to Earth with no on-board data compression, and processed by automatic pipelines to produce calibrated science products The in-flight performance of the instrument matches or exceeds predictions based on pre-launch testing and modelling: the photometer sensitivity is comparable to or slightly better than estimated pre-launch, and the spectrometer sensitivity is also better by a factor of 15-2

2,425 citations

Journal ArticleDOI
TL;DR: In this paper, the first results from the Gould Belt survey, obtained toward the Aquila Rift and Polaris Flare regions during the'science demonstration phase' of Herschel, were summarized.
Abstract: We summarize the first results from the Gould Belt survey, obtained toward the Aquila Rift and Polaris Flare regions during the 'science demonstration phase' of Herschel. Our 70-500 micron images taken in parallel mode with the SPIRE and PACS cameras reveal a wealth of filamentary structure, as well as numerous dense cores embedded in the filaments. Between ~ 350 and 500 prestellar cores and ~ 45-60 Class 0 protostars can be identified in the Aquila field, while ~ unbound starless cores and no protostars are observed in the Polaris field. The prestellar core mass function (CMF) derived for the Aquila region bears a strong resemblance to the stellar initial mass function (IMF), already confirming the close connection between the CMF and the IMF with much better statistics than earlier studies. Comparing and contrasting our Herschel results in Aquila and Polaris, we propose an observationally-driven scenario for core formation according to which complex networks of long, thin filaments form first within molecular clouds, and then the densest filaments fragment into a number of prestellar cores via gravitational instability.

1,542 citations