J
Jan Törnell
Researcher at University of Gothenburg
Publications - 93
Citations - 8384
Jan Törnell is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Receptor & Transgene. The author has an hindex of 39, co-authored 93 publications receiving 7986 citations. Previous affiliations of Jan Törnell include Umeå University & Astra.
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Journal ArticleDOI
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Aleksandra Trifunovic,Anna Wredenberg,Maria Falkenberg,Johannes N. Spelbrink,Anja T. Rovio,Carl E.G. Bruder,Mohammad Bohlooly-Y,Sebastian Gidlöf,Anders Oldfors,Rolf Wibom,Jan Törnell,Howard T. Jacobs,Nils-Göran Larsson +12 more
TL;DR: The results provide a causative link between mtDNA mutations and ageing phenotypes in mammals by creating homozygous knock-in mice that express a proof-reading-deficient version of PolgA, the nucleus-encoded catalytic subunit of mtDNA polymerase.
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Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice
Klara Sjögren,Jun-Li Liu,Kristina Blad,Stanko Skrtic,Olle Vidal,Ville Wallenius,Derek LeRoith,Jan Törnell,Olle Isaksson,John-Olov Jansson,Claes Ohlsson +10 more
TL;DR: It is concluded that postnatal body growth is preserved despite complete absence of IGF-I production by the hepatocytes, suggesting that the liver is the principal source of IGF -I in the blood.
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PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Hans Boström,Karen Willetts,Karen Willetts,Milos Pekny,Per Levéen,Per Lindahl,Håkan Hedstrand,Marcela Pekna,Mats Hellström,Samuel Gebre-Medhin,Martin Schalling,Mia Nilsson,Siri Kurland,Jan Törnell,John K. Heath,Christer Betsholtz +15 more
TL;DR: The two PDGF null phenotypes reveal analogous morphogenetic functions for myofibroblast-type cells in lung and kidney organogenesis, and show that PDGF-B is required in the ontogeny of kidney mesangial cells.
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Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice
TL;DR: Activation of the PRLR is sufficient for induction of mammary carcinomas in mice, while activation of the GHR is not sufficient for mammary tumor formation.
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Transgenic Mice Overexpressing the Prolactin Gene Develop Dramatic Enlargement of the Prostate Gland
TL;DR: In mice overexpressing the bovine GH gene, displaying elevated IGF-1 levels, the prostate gland was slightly larger compared with normal mice, indicating that the effect of PRL was not primarily mediated through elevated p...