J
Jan van Benthem
Researcher at Centre for Health Protection
Publications - 73
Citations - 3151
Jan van Benthem is an academic researcher from Centre for Health Protection. The author has contributed to research in topics: Genotoxicity & Gene mutation. The author has an hindex of 25, co-authored 71 publications receiving 2759 citations.
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Journal ArticleDOI
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
Sarah Adler,David A. Basketter,Stuart Creton,Olavi Pelkonen,Jan van Benthem,Valérie Zuang,Klaus Ejner Andersen,Alexandre Angers-Loustau,Aynur O. Aptula,Anna Bal-Price,Emilio Benfenati,Ulrike Bernauer,J.G.M. Bessems,Frédéric Y. Bois,Alan R. Boobis,Esther Brandon,Susanne Bremer,Thomas H. Broschard,Silvia Casati,Sandra Coecke,Raffaella Corvi,Mark T. D. Cronin,George P. Daston,Wolfgang Dekant,Susan P. Felter,Elise Grignard,Ursula Gundert-Remy,Tuula Heinonen,Ian Kimber,Jos C. S. Kleinjans,Hannu Komulainen,Reinhard Kreiling,Joachim Kreysa,Sofia B. Leite,George Loizou,Gavin Maxwell,Paolo Mazzatorta,Sharon Munn,Stefan Pfuhler,Pascal Phrakonkham,Aldert H. Piersma,Albrecht Poth,Pilar Prieto,Guillermo Repetto,Vera Rogiers,Greet Schoeters,Michael Schwarz,Rositsa Serafimova,Hanna Tähti,Emanuela Testai,Joost H.M. van Delft,Henk Van Loveren,Mathieu Vinken,Andrew Worth,Jose-Manuel Zaldivar +54 more
TL;DR: In this paper, Adler et al. present a survey of the authors' work in the field of bioinformatics, including the following authors:Sarah AdlerDavid BasketterStuart CretonOlavi PelkonenJan van BenthemValerie Zuang • Klaus Ejner AndersenAlexandre Angers-LoustauAynur AptulaAnna Bal-PriceEmilio Benfenati • Ulrike BernauerJos BessemsFrederic Y. BoisAlan BoobisEsther BrandonSusanne Bremer • Thomas
Journal ArticleDOI
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop.
David Kirkland,Stefan Pfuhler,David Tweats,Marilyn J. Aardema,Raffaella Corvi,Firouz Darroudi,Azeddine Elhajouji,Hansruedi Glatt,Paul W. Hastwell,M. Hayashi,Peter Kasper,Stephan Kirchner,Anthony M. Lynch,Daniel Marzin,Daniela Maurici,Jean-Roc Meunier,Lutz Müller,Gerhard J. Nohynek,James M. Parry,Elizabeth M. Parry,Véronique Thybaud,Ray Tice,Jan van Benthem,Philippe Vanparys,Paul D. White +24 more
TL;DR: It was concluded that better guidance on the likely mechanisms resulting in positive results that are not biologically relevant for human health, and how to obtain evidence for those mechanisms, is needed both for practitioners and regulatory reviewers.
Journal ArticleDOI
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
TL;DR: It is demonstrated that human non-genotoxic carcinogens were present in 12% (45/371) of IARC's Groups 1, 2A and 2B carcinogens and that a potential hazard was associated with 27% (12/45) of them, and it is suggested that for all genotoxic chemicals, the mode of action is investigated for hazard and risk evaluation.
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Differential Contributions of Mammalian Rad54 Paralogs to Recombination, DNA Damage Repair, and Meiosis
Joanna Wesoly,Sheba Agarwal,Stefan Sigurdsson,Wendy Bussen,Stephen Van Komen,Jian Qin,Harry van Steeg,Jan van Benthem,Evelyne Wassenaar,Willy M. Baarends,Mehrnaz Ghazvini,Agnieszka A. Tafel,Helen Heath,Niels Galjart,Jeroen Essers,J. Anton Grootegoed,Norman Arnheim,Olga Bezzubova,Jean-Marie Buerstedde,Patrick Sung,Roland Kanaar +20 more
TL;DR: It is shown that a mammalian Rad54 paralog, Rad54B, displays physical and functional interactions with Rad51 and DNA that are similar to those of Rad54 that suggest that the paralogs possibly function in a tissue-specific manner.
Journal ArticleDOI
Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests.
David Kirkland,Peter Kasper,Hans Jörg Martus,Lutz Müller,Jan van Benthem,Federica Madia,Raffaella Corvi +6 more
TL;DR: Three recommended lists of chemicals that would be appropriate to evaluate the sensitivity and specificity of new/modified mammalian cell genotoxicity tests are updated and how these should be used for any test evaluation program is described.