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Jane C. Figueiredo

Bio: Jane C. Figueiredo is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Colorectal cancer & Cancer. The author has an hindex of 38, co-authored 173 publications receiving 5877 citations. Previous affiliations of Jane C. Figueiredo include Memorial Sloan Kettering Cancer Center & University of Southern California.


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Journal ArticleDOI
TL;DR: In the UK and the USA, risk of reporting a positive test for COVID-19 was increased among front-line health-care workers, and adequacy of PPE, clinical setting, and ethnic background were also important factors.
Abstract: Summary Background Data for front-line health-care workers and risk of COVID-19 are limited. We sought to assess risk of COVID-19 among front-line health-care workers compared with the general community and the effect of personal protective equipment (PPE) on risk. Methods We did a prospective, observational cohort study in the UK and the USA of the general community, including front-line health-care workers, using self-reported data from the COVID Symptom Study smartphone application (app) from March 24 (UK) and March 29 (USA) to April 23, 2020. Participants were voluntary users of the app and at first use provided information on demographic factors (including age, sex, race or ethnic background, height and weight, and occupation) and medical history, and subsequently reported any COVID-19 symptoms. We used Cox proportional hazards modelling to estimate multivariate-adjusted hazard ratios (HRs) of our primary outcome, which was a positive COVID-19 test. The COVID Symptom Study app is registered with ClinicalTrials.gov, NCT04331509. Findings Among 2 035 395 community individuals and 99 795 front-line health-care workers, we recorded 5545 incident reports of a positive COVID-19 test over 34 435 272 person-days. Compared with the general community, front-line health-care workers were at increased risk for reporting a positive COVID-19 test (adjusted HR 11·61, 95% CI 10·93–12·33). To account for differences in testing frequency between front-line health-care workers and the general community and possible selection bias, an inverse probability-weighted model was used to adjust for the likelihood of receiving a COVID-19 test (adjusted HR 3·40, 95% CI 3·37–3·43). Secondary and post-hoc analyses suggested adequacy of PPE, clinical setting, and ethnic background were also important factors. Interpretation In the UK and the USA, risk of reporting a positive test for COVID-19 was increased among front-line health-care workers. Health-care systems should ensure adequate availability of PPE and develop additional strategies to protect health-care workers from COVID-19, particularly those from Black, Asian, and minority ethnic backgrounds. Additional follow-up of these observational findings is needed. Funding Zoe Global, Wellcome Trust, Engineering and Physical Sciences Research Council, National Institutes of Health Research, UK Research and Innovation, Alzheimer's Society, National Institutes of Health, National Institute for Occupational Safety and Health, and Massachusetts Consortium on Pathogen Readiness.

1,556 citations

Journal ArticleDOI
TL;DR: To eliminate cancer health disparities, it will be necessary to facilitate access to, and utilisation of, health services to all individuals, and to address structural inequities, including racism, that disproportionally affect racial/ethnic minorities in the USA.
Abstract: There are well-established disparities in cancer incidence and outcomes by race/ethnicity that result from the interplay between structural, socioeconomic, socio-environmental, behavioural and biological factors. However, large research studies designed to investigate factors contributing to cancer aetiology and progression have mainly focused on populations of European origin. The limitations in clinicopathological and genetic data, as well as the reduced availability of biospecimens from diverse populations, contribute to the knowledge gap and have the potential to widen cancer health disparities. In this review, we summarise reported disparities and associated factors in the United States of America (USA) for the most common cancers (breast, prostate, lung and colon), and for a subset of other cancers that highlight the complexity of disparities (gastric, liver, pancreas and leukaemia). We focus on populations commonly identified and referred to as racial/ethnic minorities in the USA-African Americans/Blacks, American Indians and Alaska Natives, Asians, Native Hawaiians/other Pacific Islanders and Hispanics/Latinos. We conclude that even though substantial progress has been made in understanding the factors underlying cancer health disparities, marked inequities persist. Additional efforts are needed to include participants from diverse populations in the research of cancer aetiology, biology and treatment. Furthermore, to eliminate cancer health disparities, it will be necessary to facilitate access to, and utilisation of, health services to all individuals, and to address structural inequities, including racism, that disproportionally affect racial/ethnic minorities in the USA.

383 citations

Journal ArticleDOI
Mev Dominguez-Valentin1, Julian R. Sampson2, Toni T. Seppälä3, Sanne W. ten Broeke4, John-Paul Plazzer5, Sigve Nakken1, Christoph Engel6, Stefan Aretz7, Mark A. Jenkins8, Lone Sunde9, Lone Sunde10, Inge Bernstein11, Gabriel Capellá, Francesc Balaguer12, Huw D. Thomas13, D. Gareth Evans14, D. Gareth Evans15, John Burn16, Marc S. Greenblatt17, Eivind Hovig1, Wouter H. de Vos tot Nederveen Cappel, Rolf H. Sijmons18, Lucio Bertario19, Maria Grazia Tibiletti, Giulia Martina Cavestro20, Annika Lindblom21, Adriana Della Valle, Francisco López-Köstner, Nathan Gluck22, Lior H. Katz23, Karl Heinimann24, Carlos A. Vaccaro25, Reinhard Büttner26, Heike Görgens27, Elke Holinski-Feder28, Monika Morak28, Stefanie Holzapfel7, Robert Hüneburg29, Magnus von Knebel Doeberitz30, Magnus von Knebel Doeberitz31, Markus Loeffler6, Nils Rahner32, Hans K. Schackert27, Verena Steinke-Lange28, Wolff Schmiegel33, Deepak Vangala33, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo34, Laura Renkonen-Sinisalo3, John L. Hopper8, Aung Ko Win8, Robert W. Haile35, Noralane M. Lindor36, Steven Gallinger37, Loic Le Marchand38, Polly A. Newcomb39, Jane C. Figueiredo40, Stephen N. Thibodeau36, Karin Wadt, Christina Therkildsen41, Henrik Okkels11, Zohreh Ketabi41, Leticia Moreira12, Ariadna Sánchez12, Miquel Serra-Burriel12, Marta Pineda, Matilde Navarro, Ignacio Blanco, Kate Green15, Fiona Lalloo15, Emma J Crosbie14, James Hill15, Oliver G. Denton2, Ian M. Frayling2, Einar Andreas Rødland1, Hans F. A. Vasen42, Miriam Mints43, Florencia Neffa, Patricia Esperon, Karin Alvarez, Revital Kariv22, Guy Rosner22, Tamara Alejandra Piñero25, María Laura Gonzalez25, Pablo Kalfayan25, Douglas Tjandra8, Ingrid Winship8, Ingrid Winship5, Finlay A. Macrae8, Finlay A. Macrae5, Gabriela Möslein, Jukka-Pekka Mecklin44, Maartje Nielsen4, Pål Møller1, Pål Møller45 
TL;DR: Management guidelines for Lynch syndrome may require revision in light of these different gene and gender-specific risks and the good prognosis for the most commonly associated cancers.

334 citations

Journal ArticleDOI
TL;DR: Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in disease etiology.
Abstract: To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 × 10-8, bringing the number of known independent signals for CRC to ~100. New signals implicate lower-frequency variants, Kruppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.

324 citations

Journal ArticleDOI
TL;DR: The prevalence of symptoms that characterise an omicron infection differs from those of the delta SARS-CoV-2 variant, apparently with less involvement of the lower respiratory tract and reduced probability of hospital admission.

291 citations


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01 Feb 2015
TL;DR: In this article, the authors describe the integrative analysis of 111 reference human epigenomes generated as part of the NIH Roadmap Epigenomics Consortium, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression.
Abstract: The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here we describe the integrative analysis of 111 reference human epigenomes generated as part of the programme, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression. We establish global maps of regulatory elements, define regulatory modules of coordinated activity, and their likely activators and repressors. We show that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease. Our results demonstrate the central role of epigenomic information for understanding gene regulation, cellular differentiation and human disease.

4,409 citations

01 Jan 2020
TL;DR: Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
Abstract: Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

4,408 citations

01 Apr 2012
TL;DR: International experts in cancer prevention analyse global research on diet nutrition physical activity cancer and make public health policy recommendations, the fractions of cancer attributable to potentially modifiable factors are analyzed.
Abstract: physical activity and cancer fact sheet national cancer on this page what is physical activity what is known about the relationship between physical activity and cancer risk how might physical activity be, diet and cancer report american institute for cancer the american institute for cancer research aicr is the cancer charity that fosters research on diet and cancer prevention and educates the public about the results, download resources and toolkits world cancer research downloads for scientists from the wcrf aicr third expert report diet nutrition physical activity and cancer a global perspective, nutritional science university of washington school of public health school of public health nutritional science detailed course offerings time schedule are available for spring quarter 2019, 2019 aicr research conference american institute for about aicr we fund cutting edge research and give people practical tools and information to help them prevent and survive cancer more about aicr, agence fruits et l gumes frais aprifel the global fruit and veg newsletter is a monthly newsletter distributing to 29 countries involved in the promotion of the consumption of fruit and vegetable worldwide, world cancer research fund international we are experts in cancer prevention we analyse global research on diet nutrition physical activity cancer and make public health policy recommendations, the fractions of cancer attributable sciencedirect com a proportion of cancers at many body sites are attributable to potentially modifiable factors no global summaries of the preventable cancer burden have been, who controlling the global obesity epidemic more information obesity and overweight fact sheet who global strategy on diet physical activity and health who global database on body mass index, espen guidelines on nutrition in cancer patients gl nutrition in cancer patients outline o methods o1 basic information o2 methods o3 post publication impact a background a1 catabolic alterations in, un news global perspective human stories un news produces daily news content in arabic chinese english french kiswahili portuguese russian and spanish and weekly programmes in hindi urdu and bangla, recommended community strategies and measurements to table continued summary of recommended community strategies and measurements to prevent obesity in the united states strategies to encourage physical, food as medicine preventing treating the most dreaded food as medicine preventing treating the most dreaded diseases with diet, video resources bc cancer these videos help patients learn about their cancer and its treatment, prostate cancer nutrition and dietary supplements pdq nutrition methods and dietary supplements have been studied for prostate cancer prevention or treatment read about the history of research laboratory, who europe food safety food safety ingestion and handling of contaminated food causes significant illness and death worldwide across the who european region foodborne diseases, creating healthy food and eating environments policy and food and eating environments likely contribute to the increasing epidemic of obesity and chronic diseases over and above individual factors such as knowledge skills, health risks obesity prevention source harvard t h obesity and reproduction obesity can influence various aspects of reproduction from sexual activity to conception among women the association between, top nutrition schools undergraduate degree programs ncr want to know the top nutrition schools and best undergraduate degree programs here we review analyze rank rate them figure out which is best for you , overeating caloric restriction and breast cancer risk by this study analyzes the association of excessive energy intake and caloric restriction with breast cancer bc risk taking into account the individual, calcium what s best for your bones and health the possible increased risk of ovarian cancer high levels of galactose a sugar released by the digestion of lactose in milk have been studied as being, cancer protocol nutrition supplements cancer protocol nutrition supplements herbs enzymes note do not email me unless you would like a personalized protocol free with a suggested donation of 250

2,202 citations

01 Jan 2010
TL;DR: The proofs of your article above are available for your review and can be downloaded using the file located at this URL address: http://rapidproof.cadmus.com/RapidProof/retrieval/index.jsp.
Abstract: IOVS MS 11-7777 (Article 2207) Proofs Available _______________________ Dear Author: The proofs of your article above are available for your review. Please download the file located at this URLaddress: http://rapidproof.cadmus.com/RapidProof/retrieval/index.jsp Login: [your e-mail address]Password: 99S4UntgTcU9 You will need to have Adobe Acrobat Reader software to read this file. This is free software and is availablefor user downloading at http://www.adobe.com/products/acrobat/readstep.html. If you experience technical problems, please contact Tracey Ritchey(e-mail: ritcheyt@cadmus.com; phone: 717-721-2646) This file contains: -- Instructions to Author-- Adobe Acrobat Comments and Notes Instructions-- Publication Fees and Reprint Order Form-- Page Proofs for your article, table of contents precis blurb, and author queries - containing 5 pages Please insert your comments electronically (instructions enclosed), or print the PDF proofs and add yourcomments manually. Follow the enclosed instructions for emailing, faxing, or mailing your corrections.Return all materials within 48 hours (two business days) to assure quick publication of your article. NOTE: Effective with the January 2010 issue IOVS will be available online only. No printed issues will beproduced. Printed reprints may still be ordered using the file provided. If you have any questions regarding your article, please contact me. ALWAYS INCLUDE YOURARTICLE NO. (IOVS MS 11-7777) WITH ALL CORRESPONDENCE. Cathy FreyTel: 717-721-2616Fax: 717-738-9479 or 717-738-9478freyc@cadmus.com

1,575 citations