J
Janet Gukasyan
Researcher at University of Southern California
Publications - 8
Citations - 269
Janet Gukasyan is an academic researcher from University of Southern California. The author has contributed to research in topics: Genome-wide association study & Internal medicine. The author has an hindex of 5, co-authored 6 publications receiving 79 citations.
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Journal ArticleDOI
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma.
Yi Han,Qiong Jia,Pedram Shafiei Jahani,Benjamin P. Hurrell,Calvin Pan,Pin Huang,Janet Gukasyan,Nicholas C. Woodward,Eleazar Eskin,Frank D. Gilliland,Omid Akbari,Jaana Hartiala,Hooman Allayee +12 more
TL;DR: A genome-wide analysis for asthma is reported, identifying 66 previously unknown asthma loci and demonstrating that the susceptibility alleles in these regions are associated with risk to a greater extent in men than women, and a murine anti-CD52 antibody mimics the immune cell-depleting effects of a clinically used human anti- CD52 antibody and reduces allergen-induced airway hyperreactivity in mice.
Journal ArticleDOI
Genome-wide analysis identifies novel susceptibility loci for myocardial infarction
Jaana Hartiala,Yi Han,Qiong Jia,James R. Hilser,Pin Huang,Janet Gukasyan,William S Schwartzman,Zhiheng Cai,Subarna Biswas,David-Alexandre Trégouët,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Marcus M. Seldin,Calvin Pan,Margarete Mehrabian,Aldons J. Lusis,Peter Bazeley,Yan V. Sun,Chang Liu,Arshed A. Quyyumi,Markus Scholz,Joachim Thiery,Graciela E. Delgado,Marcus E. Kleber,Winfried März,Winfried März,Winfried März,Laurence J. Howe,Folkert W. Asselbergs,Folkert W. Asselbergs,Marion van Vugt,Georgios J. Vlachojannis,Riyaz S. Patel,Riyaz S. Patel,Leo-Pekka Lyytikäinen,Mika Kähönen,Terho Lehtimäki,Tuomo Nieminen,Pekka Kuukasjärvi,Jari Laurikka,Xuling Chang,Xuling Chang,Chew-Kiat Heng,Chew-Kiat Heng,Rong Jiang,William E. Kraus,Elizabeth R. Hauser,Jane F. Ferguson,Muredach P. Reilly,Kaoru Ito,Satoshi Koyama,Yoichiro Kamatani,Yoichiro Kamatani,Issei Komuro,Lindsey K. Stolze,Casey E. Romanoski,Mohammad Daud Khan,Adam W. Turner,Clint L. Miller,Redouane Aherrahrou,Mete Civelek,Lijiang Ma,Johan L.M. Björkegren,Johan L.M. Björkegren,S. Ram Kumar,W.H. Wilson Tang,Stanley L. Hazen,Hooman Allayee +68 more
TL;DR: A large-scale analysis comprising ∼831 000 subjects revealed novel genetic determinants of MI and implicated SLC44A3 in the pathophysiology of vulnerable plaques and thrombus formation as mentioned in this paper.
Journal ArticleDOI
Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression.
Nisreen Nimer,Ibrahim Choucair,Zeneng Wang,Ina Nemet,Lin Li,Janet Gukasyan,Taylor L. Weeks,Naim Alkhouri,Nizar N. Zein,W.H. Wilson Tang,W.H. Wilson Tang,Michael A. Fischbach,J. Mark Brown,Hooman Allayee,Srinivasan Dasarathy,Srinivasan Dasarathy,Valentin Gogonea,Valentin Gogonea,Valentin Gogonea,Stanley L. Hazen +19 more
TL;DR: Circulating bile acid levels are associated with histopathological and genetic determinants of the transition from simple hepatic steatosis into NASH, and their associations with genetic variants linked to NAFLD and NASH are examined.
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Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection.
James R. Hilser,Yi Han,Subarna Biswas,Janet Gukasyan,Zhiheng Cai,Ruowei Zhu,W.H. Wilson Tang,W.H. Wilson Tang,Arjun Deb,Aldons J. Lusis,Jaana Hartiala,Hooman Allayee +11 more
TL;DR: In this article, the relationship between severity of COVID-19 and metabolic syndrome-related serum biomarkers measured prior to SARS-CoV-2 infection was investigated using data from the UK Biobank.
Journal ArticleDOI
Genetic determinants of circulating glycine levels and risk of coronary artery disease.
Qiong Jia,Yi Han,Pin Huang,Pin Huang,Nicholas C. Woodward,Janet Gukasyan,Johannes Kettunen,Mika Ala-Korpela,Olga Anufrieva,Qin Wang,Qin Wang,Markus Perola,Markus Perola,Markus Perola,Olli T. Raitakari,Olli T. Raitakari,Terho Lehtimäki,Jorma Viikari,Jorma Viikari,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Michael Boehnke,Markku Laakso,Karen L. Mohlke,Oliver Fiehn,Zeneng Wang,W.H. Wilson Tang,Stanley L. Hazen,Stanley L. Hazen,Jaana Hartiala,Hooman Allayee +31 more
TL;DR: In this article, sexually dimorphic associations between the carbamoyl-phosphate synthase 1 locus and the metabolic pathway leading from choline to urea were found.