J
Janet L. Goldstein
Researcher at Johns Hopkins University
Publications - 4
Citations - 2889
Janet L. Goldstein is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 4, co-authored 4 publications receiving 2809 citations. Previous affiliations of Janet L. Goldstein include Johns Hopkins University School of Medicine.
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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Laura J. Scott,Karen L. Mohlke,Lori L. Bonnycastle,Cristen J. Willer,Yun Li,William L. Duren,Michael R. Erdos,Heather M. Stringham,Peter S. Chines,Anne U. Jackson,Ludmila Prokunina-Olsson,Chia-Jen Ding,Amy J. Swift,Narisu Narisu,Tianle Hu,Randall Pruim,Rui Xiao,Xiao-Yi Li,Karen N. Conneely,Nancy Riebow,Andrew G. Sprau,Maurine Tong,Peggy P. White,Kurt N. Hetrick,Michael W. Barnhart,Craig W. Bark,Janet L. Goldstein,Lee Watkins,Fang Xiang,Jouko Saramies,Thomas A. Buchanan,Richard M. Watanabe,Timo T. Valle,Leena Kinnunen,Gonçalo R. Abecasis,Elizabeth W. Pugh,Kimberly F. Doheny,Richard N. Bergman,Jaakko Tuomilehto,Francis S. Collins,Michael Boehnke +40 more
TL;DR: The number of T2D loci now confidently identified to at least 10 is confirmed, and it is confirmed that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T1D risk.
Journal ArticleDOI
The Development of a Highly Informative Mouse Simple Sequence Length Polymorphism (SSLP) Marker Set and Construction of a Mouse Family Tree Using Parsimony Analysis
Philip D. Witmer,Kimberly F. Doheny,Marcia Adams,C. D. Boehm,Jane S. Dizon,Janet L. Goldstein,Tira M. Templeton,Ariana M. Wheaton,Penny N. Dong,Elizabeth W. Pugh,Robert L. Nussbaum,Kent W. Hunter,Jennifer A. Kelmenson,Lucy B. Rowe,Michael J. Brownstein +14 more
TL;DR: With this large data set, it is sought to reconstruct a phylogenetic history of the laboratory mouse using Wagner parsimony analysis and the results are largely congruent with the known history of inbred mouse strains.
Journal ArticleDOI
A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q.
Rasika A. Mathias,Peisong Gao,Janet L. Goldstein,Alexander F. Wilson,Elizabeth W. Pugh,Paulette Furbert-Harris,Georgia M. Dunston,Floyd J. Malveaux,Alkis Togias,Kathleen C. Barnes,Terri H. Beaty,Shau Ku Huang +11 more
TL;DR: It is demonstrated that GrASP makes it easier to visualize, summarize and prioritize regions of interest from sliding window haplotype analysis, based jointly on the p-value from all the tests from these windows and the building of haplotypes of significance in the region.
Journal ArticleDOI
Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits.
Alison P. Klein,Ya Yu Tsai,Priya Duggal,Elizabeth M. Gillanders,Michael W. Barnhart,Rasika A. Mathias,Ian P. Dusenberry,Amy Turiff,Peter S. Chines,Janet L. Goldstein,Robert Wojciechowski,Wayne A. Hening,Elizabeth W. Pugh,Joan E. Bailey-Wilson +13 more
TL;DR: Their results showed that information content increased with increased map density, and for the homogeneous, completely penetrant traits the authors created, there was only a modest difference in ability to detect trait loci.