Janette Mezeyova

TL;DR: Simulation of α1G, α1H, and α1I T-type channels in a thalamic neuron model cell produced unique firing patterns typical of different brain nuclei and suggests that the three channel types make distinct contributions to neuronal physiology.

TL;DR: The findings suggest that several of the Cav3.2 mutants allow for greater calcium influx during physiological activation and in the case of F161L and E282K can result in channel openings at more hyperpolarized potentials, which may underlie the propensity for seizures in patients with CAE.

TL;DR: The ability of the T-type Ca2+ channel antagonists to inhibit absence seizures and to reduce the duration and cycle frequency of spike-and-wave discharges suggests that these agents have a unique mechanism of action on pathological thalamocortical oscillatory activity distinct from current drugs used in clinical practice.

TL;DR: The findings indicate that T-type Ca channels are potently blocked by a subset of neuroleptic agents and suggest that the action of these drugs on T- type Ca channels may significantly contribute to their therapeutic efficacy.

TL;DR: Cannabis sativa's mode of action likely involves compound partitioning in lipid membranes, which alters membrane fluidity affecting gating, and undetermined direct interactions with sodium and potassium channels, whose combined effects are loss of channel excitability.