J
Janice L. Holton
Researcher at UCL Institute of Neurology
Publications - 341
Citations - 24830
Janice L. Holton is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Progressive supranuclear palsy & Parkinson's disease. The author has an hindex of 78, co-authored 336 publications receiving 21608 citations. Previous affiliations of Janice L. Holton include University College London & Prince of Wales Medical Research Institute.
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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
Jia-Yi Li,Elisabet Englund,Janice L. Holton,Denis Soulet,Peter Hagell,Andrew J. Lees,Tammaryn Lashley,Niall Quinn,Stig Rehncrona,Anders Björklund,Håkan Widner,Tamas Revesz,Olle Lindvall,Patrik Brundin +13 more
TL;DR: Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11–16 years) developed α-synuclein–positive Lewy bodies in grafted neurons, providing the first evidence, to the authors' knowledge, that the disease can propagate from host to graft cells.
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A common LRRK2 mutation in idiopathic Parkinson's disease
William P. Gilks,Patrick M. Abou-Sleiman,Sonia Gandhi,Shushant Jain,Andrew B. Singleton,Andrew J. Lees,Karen Shaw,Kailash P. Bhatia,Vincenzo Bonifati,Niall Quinn,John B. Lynch,Daniel G. Healy,Janice L. Holton,Tamas Revesz,Nicholas W. Wood +14 more
TL;DR: It is shown that a common single Mendelian mutation, 2877510 g-->A, which produces a glycine to serine aminoacid substitution at codon 2019 (Gly2019 ser), in idiopathic Parkinson's disease, and suggested that testing for this mutation will be important in the management and genetic counselling of patients with Parkinson's Disease.
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Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease
Juliane Neumann,Jose Bras,Jose Bras,Emma Deas,Sean S. O'Sullivan,Laura Parkkinen,Robin H. Lachmann,Abi Li,Janice L. Holton,Rita Guerreiro,Rita Guerreiro,Reema Paudel,Badmavady Segarane,Andrew B. Singleton,Andrew J. Lees,John Hardy,Henry Houlden,Tamas Revesz,Nicholas W. Wood +18 more
TL;DR: It is demonstrated that GBA mutations are found in British subjects at a higher frequency than any other known Parkinson's disease gene and suggested that to date, this is the most common genetic factor identified for the disease.
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Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism.
David R. Williams,Rohan de Silva,Dominic C. Paviour,Alan M. Pittman,Hilary Watt,Linda Kilford,Janice L. Holton,Tamas Revesz,Andrew J. Lees +8 more
TL;DR: It is proposed that PSP-P represents a second discrete clinical phenotype that needs to be clinically distinguished from classical PSP (RS), and the different tau isoform deposition in the basal pons suggests that this may ultimately prove to be a discrete nosological entity.
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Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
Yaroslau Compta,Laura Parkkinen,Sean S. O'Sullivan,Jana Vandrovcova,Janice L. Holton,Catherine A. Collins,Tammaryn Lashley,Constantinos Kallis,David R. Williams,David R. Williams,Rohan de Silva,Andrew J. Lees,Tamas Revesz +12 more
TL;DR: A combination ofLewy- and Alzheimer-type pathologies is a robust pathological correlate of dementia in Parkinson's disease, with quantitative and semi-quantitative assessment of Lewy pathology being more informative than Braak α-synuclein stages.