J
Janina Ratajczak
Researcher at University of Louisville
Publications - 248
Citations - 20532
Janina Ratajczak is an academic researcher from University of Louisville. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 66, co-authored 235 publications receiving 19136 citations. Previous affiliations of Janina Ratajczak include Pomeranian Medical University & Jagiellonian University.
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Journal ArticleDOI
Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery.
Janina Ratajczak,Katarzyna Miekus,Magdalena Kucia,Jin Zhang,Ryan Reca,Petr Dvorak,Mariusz Z. Ratajczak +6 more
TL;DR: ES-MV isolated from murine ES cells in serum-free cultures significantly enhanced survival and improved expansion of murine HPC, and upregulated the expression of early pluripotent and early hematopoietic stem cells in these cells.
Journal ArticleDOI
Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication.
TL;DR: The pleiotropic effects of MV that are important for communication between cells, as well as the role of MV in carcinogenesis, coagulation, immune responses and modulation of susceptibility/infectability of cells to retroviruses or prions are discussed.
Journal ArticleDOI
Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia
W.-J. Song,M. G. Sullivan,R. D. Legare,S Hutchings,Xiaolian Tan,Dubravka Kufrin,Janina Ratajczak,I. C. Resende,C. Haworth,R. Hock,Mignon L. Loh,C. Felix,Denis-Claude Roy,Lambert Busque,David M. Kurnit,Cheryl L. Willman,Alan M. Gewirtz,Nancy A. Speck,John H. Bushweller,Fugen Li,K. Gardiner,Mortimer Poncz,John M. Maris,D. G. Gilliland,D. G. Gilliland +24 more
TL;DR: The findings support a model for FPD/AML in which haploinsufficiency of CBFA2 causes an autosomal dominant congenital platelet defect and predisposes to the acquisition of additional mutations that cause leukaemia.
Journal ArticleDOI
Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF-1–CXCR4 Axis
Magda Kucia,Ryan Reca,Katarzyna Miekus,Jens Wanzeck,Wojtek Wojakowski,Anna Janowska-Wieczorek,Janina Ratajczak,Mariusz Z. Ratajczak +7 more
TL;DR: It is suggested that strategies aimed at modulating the SDF‐1–CXCR4 axis could have important clinical applications both in regenerative medicine to deliver normal stem cells to the tissues/organs and in clinical hematology/oncology to inhibit metastasis of cancer stem cells.
Journal ArticleDOI
Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer.
Anna Janowska-Wieczorek,Marcin Wysoczynski,Marcin Wysoczynski,Jacek Kijowski,Jacek Kijowski,Leah A. Marquez-Curtis,Leah A. Marquez-Curtis,Bogdan Machalinski,Bogdan Machalinski,Janina Ratajczak,Janina Ratajczak,Mariusz Z. Ratajczak,Mariusz Z. Ratajczak +12 more
TL;DR: It is suggested that PMV play an important role in tumor progression/metastasis and angiogenesis in lung cancer.