Janneth Gonzalez

Bio: Janneth Gonzalez is an academic researcher from Pontifical Xavierian University. The author has contributed to research in topics: Neuroprotection & Medicine. The author has an hindex of 21, co-authored 65 publications receiving 2214 citations.

MCYT baseline corpus: a bimodal biometric database

Abstract: The current need for large multimodal databases to evaluate automatic biometric recognition systems has motivated the development of the MCYT bimodal database. The main purpose has been to consider a large scale population, with statistical significance, in a real multimodal procedure, and including several sources of variability that can be found in real environments. The acquisition process, contents and availability of the single-session baseline corpus are fully described. Some experiments showing consistency of data through the different acquisition sites and assessing data quality are also presented.

Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

Abstract: TThe blood–brain barrier (BBB) is a tightly regulated interface in the Central Nervous System that regulates the exchange of molecules in and out from the brain thus maintaining the CNS homeostasis. It is mainly composed of endothelial cells, pericytes and astrocytes that create a neurovascular unit with the adjacent neurons. Astrocytes are essential for the formation and maintenance of the BBB by providing secreted factors that lead to the adequate association between the cells of the BBB and the formation of strong tight junctions. Under neurological disorders, such as chronic cerebral ischemia, brain trauma, Epilepsy, Alzheimer and Parkinson´s Diseases, a disruption of the BBB takes place, involving a lost in the permeability of the barrier and phenotypical changes in both the endothelial cells and astrocytes. In this aspect, it has been established that the process of reactive gliosis is a common feature of astrocytes during BBB disruption, which has a detrimental effect on the barrier function and a subsequent damage in neuronal survival. In this review we discuss the implications of astrocyte functions in the protection of the BBB, and in the development of Parkinson´s disease and related disorders. Additionally, we highlight the current and future strategies in astrocyte protection aimed at the development of restorative therapies for the BBB in pathological conditions.

Effects of natural antioxidants in neurodegenerative disease

Abstract: Polyphenols are secondary metabolites with antioxidant properties and are abundant in the diet. Fruits, vegetables, herbs, and various drinks (tea, wine, and juices) are all sources of these molecules. Despite their abundance, investigations into the benefits of polyphenols in human health have only recently begun. Phenolic compounds have received increasing interest because of numerous epidemiological studies. These studies have suggested associations between the consumption of polyphenol-rich aliments and the prevention of chronic diseases, such as cancer, cardiovascular diseases, and neurodegenerative diseases. More specifically, in the last 10 years literature on the neuroprotective effects of a polyphenol-rich diet has grown considerably. It has been demonstrated, in various cell culture and animal models, that these metabolites are able to protect neuronal cells by attenuating oxidative stress and damage. However, it remains unclear as to how these compounds reach the brain, what concentrations are necessary, and what biologically active forms are needed to exert beneficial effects. Therefore, further research is needed to identify the molecular pathways and intracellular targets responsible for polyphenol’s neuroprotective effects. The aim of this paper is to present various well-known dietary polyphenols and their mechanisms of neuroprotection with an emphasis on Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.

Cellular and molecular mechanisms of antioxidants in Parkinson's disease

Abstract: Parkinson’s disease (PD) is a neurodegenerative movement disorder characterized by the degeneration and progressive loss of dopaminergic neurons in the substantia nigra pars compacta. It has been suggested that oxidative stress plays a role in the etiology and progression of PD. For instance, low levels of endogenous antioxidants, increased reactive species, augmented dopamine oxidation, and high iron levels have been found in brains from PD patients. In vitro and in vivo studies of Parkinson models evaluating natural and endogenous antioxidants such as polyphenols, coenzyme Q10, and vitamins A, C, and E have shown protective effects against oxidative-induced neuronal death. In this paper, we will review the mechanisms by which polyphenols and endogenous antioxidants can produce protection. Some of the mechanisms reviewed include: scavenging nitrogen and oxygen reactive species, regulation of signaling pathways associated with cell survival and inflammation, and inhibition of synphilin-1 and alpha-synuclein aggregation.

Multimodal fusion for multimedia analysis: a survey

Abstract: This survey aims at providing multimedia researchers with a state-of-the-art overview of fusion strategies, which are used for combining multiple modalities in order to accomplish various multimedia analysis tasks. The existing literature on multimodal fusion research is presented through several classifications based on the fusion methodology and the level of fusion (feature, decision, and hybrid). The fusion methods are described from the perspective of the basic concept, advantages, weaknesses, and their usage in various analysis tasks as reported in the literature. Moreover, several distinctive issues that influence a multimodal fusion process such as, the use of correlation and independence, confidence level, contextual information, synchronization between different modalities, and the optimal modality selection are also highlighted. Finally, we present the open issues for further research in the area of multimodal fusion.

Automatic Signature Verification: The State of the Art

Abstract: In recent years, along with the extraordinary diffusion of the Internet and a growing need for personal verification in many daily applications, automatic signature verification is being considered with renewed interest. This paper presents the state of the art in automatic signature verification. It addresses the most valuable results obtained so far and highlights the most profitable directions of research to date. It includes a comprehensive bibliography of more than 300 selected references as an aid for researchers working in the field.